Protein fragments: functional and structural roles of their coevolution networks.

Small protein fragments, and not just residues, can be used as basic building blocks to reconstruct networks of coevolved amino acids in proteins. Fragments often enter in physical contact one with the other and play a major biological role in the protein. The nature of these interactions might be m...

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Autores principales:	Linda Dib, Alessandra Carbone
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c6178192fe4479092d3b2f032843345
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spelling	oai:doaj.org-article:4c6178192fe4479092d3b2f0328433452021-11-18T08:10:06ZProtein fragments: functional and structural roles of their coevolution networks.1932-620310.1371/journal.pone.0048124https://doaj.org/article/4c6178192fe4479092d3b2f0328433452012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23139761/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Small protein fragments, and not just residues, can be used as basic building blocks to reconstruct networks of coevolved amino acids in proteins. Fragments often enter in physical contact one with the other and play a major biological role in the protein. The nature of these interactions might be multiple and spans beyond binding specificity, allosteric regulation and folding constraints. Indeed, coevolving fragments are indicators of important information explaining folding intermediates, peptide assembly, key mutations with known roles in genetic diseases, distinguished subfamily-dependent motifs and differentiated evolutionary pressures on protein regions. Coevolution analysis detects networks of fragments interaction and highlights a high order organization of fragments demonstrating the importance of studying at a deeper level this structure. We demonstrate that it can be applied to protein families that are highly conserved or represented by few sequences, enlarging in this manner, the class of proteins where coevolution analysis can be performed and making large-scale coevolution studies a feasible goal.Linda DibAlessandra CarbonePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48124 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linda Dib Alessandra Carbone Protein fragments: functional and structural roles of their coevolution networks.
description	Small protein fragments, and not just residues, can be used as basic building blocks to reconstruct networks of coevolved amino acids in proteins. Fragments often enter in physical contact one with the other and play a major biological role in the protein. The nature of these interactions might be multiple and spans beyond binding specificity, allosteric regulation and folding constraints. Indeed, coevolving fragments are indicators of important information explaining folding intermediates, peptide assembly, key mutations with known roles in genetic diseases, distinguished subfamily-dependent motifs and differentiated evolutionary pressures on protein regions. Coevolution analysis detects networks of fragments interaction and highlights a high order organization of fragments demonstrating the importance of studying at a deeper level this structure. We demonstrate that it can be applied to protein families that are highly conserved or represented by few sequences, enlarging in this manner, the class of proteins where coevolution analysis can be performed and making large-scale coevolution studies a feasible goal.
format	article
author	Linda Dib Alessandra Carbone
author_facet	Linda Dib Alessandra Carbone
author_sort	Linda Dib
title	Protein fragments: functional and structural roles of their coevolution networks.
title_short	Protein fragments: functional and structural roles of their coevolution networks.
title_full	Protein fragments: functional and structural roles of their coevolution networks.
title_fullStr	Protein fragments: functional and structural roles of their coevolution networks.
title_full_unstemmed	Protein fragments: functional and structural roles of their coevolution networks.
title_sort	protein fragments: functional and structural roles of their coevolution networks.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4c6178192fe4479092d3b2f032843345
work_keys_str_mv	AT lindadib proteinfragmentsfunctionalandstructuralrolesoftheircoevolutionnetworks AT alessandracarbone proteinfragmentsfunctionalandstructuralrolesoftheircoevolutionnetworks
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Protein fragments: functional and structural roles of their coevolution networks.

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