Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity

Abstract Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In...

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Autores principales:	Simon Fish, Foteini Christidi, Efstratios Karavasilis, Georgios Velonakis, Nikolaos Kelekis, Christoph Klein, Nicholas C. Stefanis, Nikolaos Smyrnis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/4c647b422637432a9c6148ebe20912ed
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spelling	oai:doaj.org-article:4c647b422637432a9c6148ebe20912ed2021-12-02T16:04:35ZInteraction of schizophrenia and chronic cannabis use on reward anticipation sensitivity10.1038/s41537-021-00163-22334-265Xhttps://doaj.org/article/4c647b422637432a9c6148ebe20912ed2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00163-2https://doaj.org/toc/2334-265XAbstract Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In the present study eighty-nine participants divided into four groups (control chronic cannabis users and non-users; schizophrenia patient cannabis users and non-users) performed a two-choice decision task, preceded by monetary cues (high/low reward/punishment or neutral), while being scanned using functional magnetic resonance imaging. Reward and punishment anticipation resulted in activation of regions of interest including the thalamus, striatum, amygdala and insula. Chronic cannabis use and schizophrenia had opposing effects on reward anticipation sensitivity. More specifically control users and patient non-users showed faster behavioural responses and increased activity in anterior/posterior insula for high magnitude cues compared to control non-users and patient users. The same interaction pattern was observed in the activation of the right thalamus for reward versus punishment cues. This study provided evidence for interaction of chronic cannabis use and schizophrenia on reward processing and highlights the need for future research addressing the significance of this interaction for the pathophysiology of these conditions and its clinical consequences.Simon FishFoteini ChristidiEfstratios KaravasilisGeorgios VelonakisNikolaos KelekisChristoph KleinNicholas C. StefanisNikolaos SmyrnisNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Simon Fish Foteini Christidi Efstratios Karavasilis Georgios Velonakis Nikolaos Kelekis Christoph Klein Nicholas C. Stefanis Nikolaos Smyrnis Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
description	Abstract Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In the present study eighty-nine participants divided into four groups (control chronic cannabis users and non-users; schizophrenia patient cannabis users and non-users) performed a two-choice decision task, preceded by monetary cues (high/low reward/punishment or neutral), while being scanned using functional magnetic resonance imaging. Reward and punishment anticipation resulted in activation of regions of interest including the thalamus, striatum, amygdala and insula. Chronic cannabis use and schizophrenia had opposing effects on reward anticipation sensitivity. More specifically control users and patient non-users showed faster behavioural responses and increased activity in anterior/posterior insula for high magnitude cues compared to control non-users and patient users. The same interaction pattern was observed in the activation of the right thalamus for reward versus punishment cues. This study provided evidence for interaction of chronic cannabis use and schizophrenia on reward processing and highlights the need for future research addressing the significance of this interaction for the pathophysiology of these conditions and its clinical consequences.
format	article
author	Simon Fish Foteini Christidi Efstratios Karavasilis Georgios Velonakis Nikolaos Kelekis Christoph Klein Nicholas C. Stefanis Nikolaos Smyrnis
author_facet	Simon Fish Foteini Christidi Efstratios Karavasilis Georgios Velonakis Nikolaos Kelekis Christoph Klein Nicholas C. Stefanis Nikolaos Smyrnis
author_sort	Simon Fish
title	Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
title_short	Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
title_full	Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
title_fullStr	Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
title_full_unstemmed	Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
title_sort	interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c647b422637432a9c6148ebe20912ed
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Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity

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