RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy

Ning Zhao,1,2,* Zhangru Yang,2,3,* Bingxin Li,2 Jin Meng,2 Zeliang Shi,2 Ping Li,4 Shen Fu4 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Radiation Oncology, 6th People’s Hospital of Shanghai Jiao...

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Autores principales:	Zhao N, Yang ZR, Li BX, Meng J, Shi ZL, Li P, Fu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	gold nanorods triple-negative breast cancer Arg-Gly-Asp peptides integrin alphaV beta3 megavoltage radiation therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4c655bb2524c4b5fbfe01e8ed9f3c5db
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spelling	oai:doaj.org-article:4c655bb2524c4b5fbfe01e8ed9f3c5db2021-12-02T03:11:30ZRGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy1178-2013https://doaj.org/article/4c655bb2524c4b5fbfe01e8ed9f3c5db2016-10-01T00:00:00Zhttps://www.dovepress.com/rgd-conjugated-mesoporous-silica-encapsulated-gold-nanorods-enhance-th-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ning Zhao,1,2,* Zhangru Yang,2,3,* Bingxin Li,2 Jin Meng,2 Zeliang Shi,2 Ping Li,4 Shen Fu4 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Radiation Oncology, 6th People’s Hospital of Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance the effects of radiation on tumor cells, leading to further radiosensitization. The purpose of our study was to demonstrate that RGD-conjugated mesoporous silica-encapsulated gold nanorods significantly enhanced the sensitization of triple-negative breast cancer to megavoltage energy. The results indicated that RGD-conjugated mesoporous silica-encapsulated gold nanorod multifunctional nanoprobes could achieve radiosensitization in vitro and in vivo, which suggests the potential translation of this nanotechnology to clinical applications in tumor-targeting and selective therapy. Keywords: gold nanorods, triple-negative breast cancer, Arg-Gly-Asp peptides, integrin alphaV beta3, megavoltage radiation therapyZhao NYang ZRLi BXMeng JShi ZLLi PFu SDove Medical Pressarticlegold nanorodstriple-negative breast cancerArg-Gly-Asp peptidesintegrin alphaV beta3megavoltage radiation therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5595-5610 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	gold nanorods triple-negative breast cancer Arg-Gly-Asp peptides integrin alphaV beta3 megavoltage radiation therapy Medicine (General) R5-920
spellingShingle	gold nanorods triple-negative breast cancer Arg-Gly-Asp peptides integrin alphaV beta3 megavoltage radiation therapy Medicine (General) R5-920 Zhao N Yang ZR Li BX Meng J Shi ZL Li P Fu S RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
description	Ning Zhao,1,2,* Zhangru Yang,2,3,* Bingxin Li,2 Jin Meng,2 Zeliang Shi,2 Ping Li,4 Shen Fu4 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China; 2Department of Radiation Oncology, 6th People’s Hospital of Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance the effects of radiation on tumor cells, leading to further radiosensitization. The purpose of our study was to demonstrate that RGD-conjugated mesoporous silica-encapsulated gold nanorods significantly enhanced the sensitization of triple-negative breast cancer to megavoltage energy. The results indicated that RGD-conjugated mesoporous silica-encapsulated gold nanorod multifunctional nanoprobes could achieve radiosensitization in vitro and in vivo, which suggests the potential translation of this nanotechnology to clinical applications in tumor-targeting and selective therapy. Keywords: gold nanorods, triple-negative breast cancer, Arg-Gly-Asp peptides, integrin alphaV beta3, megavoltage radiation therapy
format	article
author	Zhao N Yang ZR Li BX Meng J Shi ZL Li P Fu S
author_facet	Zhao N Yang ZR Li BX Meng J Shi ZL Li P Fu S
author_sort	Zhao N
title	RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
title_short	RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
title_full	RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
title_fullStr	RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
title_full_unstemmed	RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
title_sort	rgd-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4c655bb2524c4b5fbfe01e8ed9f3c5db
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RGD-conjugated mesoporous silica-encapsulated gold nanorods enhance the sensitization of triple-negative breast cancer to megavoltage radiation therapy

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