Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S

Abstract Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccin...

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Autores principales:	Katya Galactionova, Thomas A. Smith, Melissa A. Penny
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Malaria vaccines Modelling and simulation Economic evaluation Malaria control Product development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/4c687905428b492e833955da49e3b20f
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spelling	oai:doaj.org-article:4c687905428b492e833955da49e3b20f2021-11-21T12:33:43ZInsights from modelling malaria vaccines for policy decisions: the focus on RTS,S10.1186/s12936-021-03973-y1475-2875https://doaj.org/article/4c687905428b492e833955da49e3b20f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12936-021-03973-yhttps://doaj.org/toc/1475-2875Abstract Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed product, RTS,S/AS01. The main contributions of modelling studies have been in inferring the mechanism of action and efficacy profile of RTS,S; to predicting the public health impact; and economic modelling mainly comprising cost-effectiveness analysis. The value of both product-specific and generic modelling of vaccines is highlighted.Katya GalactionovaThomas A. SmithMelissa A. PennyBMCarticleMalaria vaccinesModelling and simulationEconomic evaluationMalaria controlProduct developmentArctic medicine. Tropical medicineRC955-962Infectious and parasitic diseasesRC109-216ENMalaria Journal, Vol 20, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Malaria vaccines Modelling and simulation Economic evaluation Malaria control Product development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
spellingShingle	Malaria vaccines Modelling and simulation Economic evaluation Malaria control Product development Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Katya Galactionova Thomas A. Smith Melissa A. Penny Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S
description	Abstract Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed product, RTS,S/AS01. The main contributions of modelling studies have been in inferring the mechanism of action and efficacy profile of RTS,S; to predicting the public health impact; and economic modelling mainly comprising cost-effectiveness analysis. The value of both product-specific and generic modelling of vaccines is highlighted.
format	article
author	Katya Galactionova Thomas A. Smith Melissa A. Penny
author_facet	Katya Galactionova Thomas A. Smith Melissa A. Penny
author_sort	Katya Galactionova
title	Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S
title_short	Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S
title_full	Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S
title_fullStr	Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S
title_full_unstemmed	Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S
title_sort	insights from modelling malaria vaccines for policy decisions: the focus on rts,s
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4c687905428b492e833955da49e3b20f
work_keys_str_mv	AT katyagalactionova insightsfrommodellingmalariavaccinesforpolicydecisionsthefocusonrtss AT thomasasmith insightsfrommodellingmalariavaccinesforpolicydecisionsthefocusonrtss AT melissaapenny insightsfrommodellingmalariavaccinesforpolicydecisionsthefocusonrtss
_version_	1718418940139405312

Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S

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