Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease

Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease

Crohn’s disease is associated with altered intestinal microbiota. Here, the authors show that the microbe Atopobium parvulumis associated with Crohn’s disease patients, triggers colitis in a mouse model, and that scavenging microbe-induced hydrogen sulfide improved symptoms in mice.

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Detalles Bibliográficos
Autores principales: Walid Mottawea, Cheng-Kang Chiang, Marcus Mühlbauer, Amanda E. Starr, James Butcher, Turki Abujamel, Shelley A. Deeke, Annette Brandel, Hu Zhou, Shadi Shokralla, Mehrdad Hajibabaei, Ruth Singleton, Eric I. Benchimol, Christian Jobin, David R. Mack, Daniel Figeys, Alain Stintzi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/4c6883f1b92a41c686eb0855792ce2fa
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Descripción
Sumario:Crohn’s disease is associated with altered intestinal microbiota. Here, the authors show that the microbe Atopobium parvulumis associated with Crohn’s disease patients, triggers colitis in a mouse model, and that scavenging microbe-induced hydrogen sulfide improved symptoms in mice.

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