Protective CD4+ Th1 cell-mediated immunity is reliant upon execution of effector function prior to the establishment of the pathogen niche.

Intracellular infection with the parasite Leishmania major features a state of concomitant immunity in which CD4+ T helper 1 (Th1) cell-mediated immunity against reinfection coincides with a chronic but sub-clinical primary infection. In this setting, the rapidity of the Th1 response at a secondary...

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Auteurs principaux: Leah S Hohman, Zhirong Mou, Matheus B Carneiro, Gabriel Ferland, Rachel M Kratofil, Paul Kubes, Jude E Uzonna, Nathan C Peters
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2021
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Accès en ligne:https://doaj.org/article/4c6912c0c3984579bab3f79f849cf3a1
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