DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION

The development and progression of heart failure is associated with a variety of pathophysiological mechanisms, of particular interest is the study of the inflammatory response as a fundamental link in the pathogenesis of CHF and its main component – decompensation. An open, non-randomized, prospect...

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Autores principales:	O. N. Ogurkova, E. V. Kruchinkina, A. M. Gusakova, T. E. Suslova, V. V. Ryabov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	inflammation cytokines biomarkers heart failure myocarditis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4c6d8929b09b4552b4d156533cf9297c
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spelling	oai:doaj.org-article:4c6d8929b09b4552b4d156533cf9297c2021-11-18T08:03:51ZDYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION1563-06252313-741X10.15789/1563-0625-DCI-2280https://doaj.org/article/4c6d8929b09b4552b4d156533cf9297c2021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2427https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe development and progression of heart failure is associated with a variety of pathophysiological mechanisms, of particular interest is the study of the inflammatory response as a fundamental link in the pathogenesis of CHF and its main component – decompensation. An open, non-randomized, prospective study was carried out to evaluate the clinical and morphological features of subclinical inflammation in patients with acute decompensation of ischemic chronic heart failure with a reduced ejection fraction. The study included 25 patients with decompensated ischemic CHF with left ventricular ejection fraction < 40% aged 35 to 75 years (60.12±9.3 y. o.). In this study the dynamics of the serum content of C-reactive protein (CRP), N-terminal fragment of the brain natriuretic peptide precursor protein (NT-proBNP), soluble ST2(sST2), insulin-like growth factor-1 receptor (IGF-1R), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNFα) was performed by multiplex immunoassay using the FLEXMAP 3D. All studied patients were divided into two groups depending on the diagnosed myocarditis: patients with no signs of myocarditis and patients with myocarditis. It was found that in the group of patients with diagnosed myocarditis there was an increased content of CRP, IGF-1R, IL-6 and IL-10, TNFα compared to the group of patients without myocarditis. The median concentrations of the NT-proBNP and sST2 in both groups did not differ. At the follow-up visit a year later, there was a decrease in the content of CRP, NT-proBNP, IL-6 in both groups. In the group of patients with myocarditis, an increase in the content of sST2, IGF-1R, IL-10 was observed. Thus, the study carried out in dynamics revealed significant differences in the degree of changes in the serum activity of pro- and anti-inflammatory cytokines and biomarkers of cardiovascular risk in patients with decompensated heart failure with systolic dysfunction with diagnosed myocarditis and in its absence.O. N. OgurkovaE. V. KruchinkinaA. M. GusakovaT. E. SuslovaV. V. RyabovSPb RAACIarticleinflammationcytokinesbiomarkersheart failuremyocarditisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 839-844 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	inflammation cytokines biomarkers heart failure myocarditis Immunologic diseases. Allergy RC581-607
spellingShingle	inflammation cytokines biomarkers heart failure myocarditis Immunologic diseases. Allergy RC581-607 O. N. Ogurkova E. V. Kruchinkina A. M. Gusakova T. E. Suslova V. V. Ryabov DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION
description	The development and progression of heart failure is associated with a variety of pathophysiological mechanisms, of particular interest is the study of the inflammatory response as a fundamental link in the pathogenesis of CHF and its main component – decompensation. An open, non-randomized, prospective study was carried out to evaluate the clinical and morphological features of subclinical inflammation in patients with acute decompensation of ischemic chronic heart failure with a reduced ejection fraction. The study included 25 patients with decompensated ischemic CHF with left ventricular ejection fraction < 40% aged 35 to 75 years (60.12±9.3 y. o.). In this study the dynamics of the serum content of C-reactive protein (CRP), N-terminal fragment of the brain natriuretic peptide precursor protein (NT-proBNP), soluble ST2(sST2), insulin-like growth factor-1 receptor (IGF-1R), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNFα) was performed by multiplex immunoassay using the FLEXMAP 3D. All studied patients were divided into two groups depending on the diagnosed myocarditis: patients with no signs of myocarditis and patients with myocarditis. It was found that in the group of patients with diagnosed myocarditis there was an increased content of CRP, IGF-1R, IL-6 and IL-10, TNFα compared to the group of patients without myocarditis. The median concentrations of the NT-proBNP and sST2 in both groups did not differ. At the follow-up visit a year later, there was a decrease in the content of CRP, NT-proBNP, IL-6 in both groups. In the group of patients with myocarditis, an increase in the content of sST2, IGF-1R, IL-10 was observed. Thus, the study carried out in dynamics revealed significant differences in the degree of changes in the serum activity of pro- and anti-inflammatory cytokines and biomarkers of cardiovascular risk in patients with decompensated heart failure with systolic dysfunction with diagnosed myocarditis and in its absence.
format	article
author	O. N. Ogurkova E. V. Kruchinkina A. M. Gusakova T. E. Suslova V. V. Ryabov
author_facet	O. N. Ogurkova E. V. Kruchinkina A. M. Gusakova T. E. Suslova V. V. Ryabov
author_sort	O. N. Ogurkova
title	DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION
title_short	DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION
title_full	DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION
title_fullStr	DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION
title_full_unstemmed	DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION
title_sort	dynamic changes in cardiovascular risk biomarkers and cytokines of myocarditis-free patients with decompensated heart failure and ischemic systolic dysfunction
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/4c6d8929b09b4552b4d156533cf9297c
work_keys_str_mv	AT onogurkova dynamicchangesincardiovascularriskbiomarkersandcytokinesofmyocarditisfreepatientswithdecompensatedheartfailureandischemicsystolicdysfunction AT evkruchinkina dynamicchangesincardiovascularriskbiomarkersandcytokinesofmyocarditisfreepatientswithdecompensatedheartfailureandischemicsystolicdysfunction AT amgusakova dynamicchangesincardiovascularriskbiomarkersandcytokinesofmyocarditisfreepatientswithdecompensatedheartfailureandischemicsystolicdysfunction AT tesuslova dynamicchangesincardiovascularriskbiomarkersandcytokinesofmyocarditisfreepatientswithdecompensatedheartfailureandischemicsystolicdysfunction AT vvryabov dynamicchangesincardiovascularriskbiomarkersandcytokinesofmyocarditisfreepatientswithdecompensatedheartfailureandischemicsystolicdysfunction
_version_	1718422283876302848

DYNAMIC CHANGES IN CARDIOVASCULAR RISK BIOMARKERS AND CYTOKINES OF MYOCARDITIS-FREE PATIENTS WITH DECOMPENSATED HEART FAILURE AND ISCHEMIC SYSTOLIC DYSFUNCTION

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