Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration

Abstract The purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patien...

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Autores principales:	Maiko Maruyama-Inoue, Tatsuya Inoue, Shaheeda Mohamed, Yoko Kitajima, Shoko Ikeda, Arisa Ito, Kazuaki Kadonosono
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c6db6088e8448258ce6e7f7ac61462e
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spelling	oai:doaj.org-article:4c6db6088e8448258ce6e7f7ac61462e2021-12-02T17:38:27ZIncidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration10.1038/s41598-021-91832-w2045-2322https://doaj.org/article/4c6db6088e8448258ce6e7f7ac61462e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91832-whttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who underwent ≥ 10 intravitreal anti-VEGF injections between April 2009 and December 2019 was conducted. Elevated IOP was defined as IOP ≥ 25 mmHg at one visit. Cases with elevated IOP resulting from IVI were identified. Furthermore, the association between elevated IOP and some parameters, as the risk factors that influence elevated IOP, was investigated. A total of 402 eyes of 370 patients were included in this study. Twenty-eight eyes of 26 patients (7.0%) were identified as cases with elevated IOP after IVI. The mean time of elevation after baseline was 50.6 ± 26.5 months. History of glaucoma (p = 0.021; odds ratio, 5.85), treatment modality (p = 0.019; odds ratio, 6.32), and total number of injections (p = 0.003; odds ratio, 1.03) were significantly associated with elevated IOP. A late complication of elevated IOP is associated with IVI in patients with AMD. Particularly, history of glaucoma and treat and extend regimen with frequent injections were found to be risk factors of elevated IOP.Maiko Maruyama-InoueTatsuya InoueShaheeda MohamedYoko KitajimaShoko IkedaArisa ItoKazuaki KadonosonoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maiko Maruyama-Inoue Tatsuya Inoue Shaheeda Mohamed Yoko Kitajima Shoko Ikeda Arisa Ito Kazuaki Kadonosono Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
description	Abstract The purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who underwent ≥ 10 intravitreal anti-VEGF injections between April 2009 and December 2019 was conducted. Elevated IOP was defined as IOP ≥ 25 mmHg at one visit. Cases with elevated IOP resulting from IVI were identified. Furthermore, the association between elevated IOP and some parameters, as the risk factors that influence elevated IOP, was investigated. A total of 402 eyes of 370 patients were included in this study. Twenty-eight eyes of 26 patients (7.0%) were identified as cases with elevated IOP after IVI. The mean time of elevation after baseline was 50.6 ± 26.5 months. History of glaucoma (p = 0.021; odds ratio, 5.85), treatment modality (p = 0.019; odds ratio, 6.32), and total number of injections (p = 0.003; odds ratio, 1.03) were significantly associated with elevated IOP. A late complication of elevated IOP is associated with IVI in patients with AMD. Particularly, history of glaucoma and treat and extend regimen with frequent injections were found to be risk factors of elevated IOP.
format	article
author	Maiko Maruyama-Inoue Tatsuya Inoue Shaheeda Mohamed Yoko Kitajima Shoko Ikeda Arisa Ito Kazuaki Kadonosono
author_facet	Maiko Maruyama-Inoue Tatsuya Inoue Shaheeda Mohamed Yoko Kitajima Shoko Ikeda Arisa Ito Kazuaki Kadonosono
author_sort	Maiko Maruyama-Inoue
title	Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_short	Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_full	Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_fullStr	Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_full_unstemmed	Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration
title_sort	incidence of elevated intraocular pressure after intravitreal injection in japanese patients with age-related macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c6db6088e8448258ce6e7f7ac61462e
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Incidence of elevated intraocular pressure after intravitreal injection in Japanese patients with age-related macular degeneration

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