Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?

The immune system protects the host from a plethora of microorganisms and toxins through its unique ability to distinguish self from non-self. To perform this delicate but essential task, the immune system relies on two lines of defense. The innate immune system, which is by nature fast acting, repr...

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Autores principales:	Esen Yonca Bassoy, Michael Walch, Denis Martinvalet
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	reactive oxygen species adaptive immunity T lymphocytes B lymphocytes tumor microenvironment Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4c6e1ee73ddf4397b93e205e297d9f6f
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spelling	oai:doaj.org-article:4c6e1ee73ddf4397b93e205e297d9f6f2021-11-30T19:35:53ZReactive Oxygen Species: Do They Play a Role in Adaptive Immunity?1664-322410.3389/fimmu.2021.755856https://doaj.org/article/4c6e1ee73ddf4397b93e205e297d9f6f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.755856/fullhttps://doaj.org/toc/1664-3224The immune system protects the host from a plethora of microorganisms and toxins through its unique ability to distinguish self from non-self. To perform this delicate but essential task, the immune system relies on two lines of defense. The innate immune system, which is by nature fast acting, represents the first line of defense. It involves anatomical barriers, physiological factors as well as a subset of haematopoietically-derived cells generically call leukocytes. Activation of the innate immune response leads to a state of inflammation that serves to both warn about and combat the ongoing infection and delivers the antigenic information of the invading pathogens to initiate the slower but highly potent and specific second line of defense, the adaptive immune system. The adaptive immune response calls on T lymphocytes as well as the B lymphocytes essential for the elimination of pathogens and the establishment of the immunological memory. Reactive oxygen species (ROS) have been implicated in many aspects of the immune responses to pathogens, mostly in innate immune functions, such as the respiratory burst and inflammasome activation. Here in this mini review, we focus on the role of ROS in adaptive immunity. We examine how ROS contribute to T-cell biology and discuss whether this activity can be extrapolated to B cells.Esen Yonca BassoyEsen Yonca BassoyMichael WalchDenis MartinvaletDenis MartinvaletFrontiers Media S.A.articlereactive oxygen speciesadaptive immunityT lymphocytesB lymphocytestumor microenvironmentImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	reactive oxygen species adaptive immunity T lymphocytes B lymphocytes tumor microenvironment Immunologic diseases. Allergy RC581-607
spellingShingle	reactive oxygen species adaptive immunity T lymphocytes B lymphocytes tumor microenvironment Immunologic diseases. Allergy RC581-607 Esen Yonca Bassoy Esen Yonca Bassoy Michael Walch Denis Martinvalet Denis Martinvalet Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
description	The immune system protects the host from a plethora of microorganisms and toxins through its unique ability to distinguish self from non-self. To perform this delicate but essential task, the immune system relies on two lines of defense. The innate immune system, which is by nature fast acting, represents the first line of defense. It involves anatomical barriers, physiological factors as well as a subset of haematopoietically-derived cells generically call leukocytes. Activation of the innate immune response leads to a state of inflammation that serves to both warn about and combat the ongoing infection and delivers the antigenic information of the invading pathogens to initiate the slower but highly potent and specific second line of defense, the adaptive immune system. The adaptive immune response calls on T lymphocytes as well as the B lymphocytes essential for the elimination of pathogens and the establishment of the immunological memory. Reactive oxygen species (ROS) have been implicated in many aspects of the immune responses to pathogens, mostly in innate immune functions, such as the respiratory burst and inflammasome activation. Here in this mini review, we focus on the role of ROS in adaptive immunity. We examine how ROS contribute to T-cell biology and discuss whether this activity can be extrapolated to B cells.
format	article
author	Esen Yonca Bassoy Esen Yonca Bassoy Michael Walch Denis Martinvalet Denis Martinvalet
author_facet	Esen Yonca Bassoy Esen Yonca Bassoy Michael Walch Denis Martinvalet Denis Martinvalet
author_sort	Esen Yonca Bassoy
title	Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
title_short	Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
title_full	Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
title_fullStr	Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
title_full_unstemmed	Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
title_sort	reactive oxygen species: do they play a role in adaptive immunity?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4c6e1ee73ddf4397b93e205e297d9f6f
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Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?

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