Role of Multiple Infections on Immunological Variation in Wild Populations

ABSTRACT A central challenge in the fields of evolutionary immunology and disease ecology is to understand the causes and consequences of natural variation in host susceptibility to infectious diseases. As hosts progress from birth to death in the wild, they are exposed to a wide variety of microorg...

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Autor principal:	Ann T. Tate
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	coinfection disease ecology ecological immunology evolutionary immunology systems biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4c6f4deb4e4b43dd8fd9a5cae9f133e9
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spelling	oai:doaj.org-article:4c6f4deb4e4b43dd8fd9a5cae9f133e92021-12-02T19:47:35ZRole of Multiple Infections on Immunological Variation in Wild Populations10.1128/mSystems.00099-192379-5077https://doaj.org/article/4c6f4deb4e4b43dd8fd9a5cae9f133e92019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00099-19https://doaj.org/toc/2379-5077ABSTRACT A central challenge in the fields of evolutionary immunology and disease ecology is to understand the causes and consequences of natural variation in host susceptibility to infectious diseases. As hosts progress from birth to death in the wild, they are exposed to a wide variety of microorganisms that influence their physical condition, immune system maturation, and susceptibility to concurrent and future infection. Thus, multiple exposures to the same or different microbes can be important environmental drivers of host immunological variation and immune priming. In this perspective, I discuss parasite infracommunity interactions and their imprint on host immunity in space and time. I further consider feedbacks from parasite community dynamics within individual hosts on the transmission of disease at higher levels of biological organization and highlight the promise of systems biology approaches, using flour beetles as an example, for studying the role of multiple infections on immunological variation in wild populations.Ann T. TateAmerican Society for Microbiologyarticlecoinfectiondisease ecologyecological immunologyevolutionary immunologysystems biologyMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	coinfection disease ecology ecological immunology evolutionary immunology systems biology Microbiology QR1-502
spellingShingle	coinfection disease ecology ecological immunology evolutionary immunology systems biology Microbiology QR1-502 Ann T. Tate Role of Multiple Infections on Immunological Variation in Wild Populations
description	ABSTRACT A central challenge in the fields of evolutionary immunology and disease ecology is to understand the causes and consequences of natural variation in host susceptibility to infectious diseases. As hosts progress from birth to death in the wild, they are exposed to a wide variety of microorganisms that influence their physical condition, immune system maturation, and susceptibility to concurrent and future infection. Thus, multiple exposures to the same or different microbes can be important environmental drivers of host immunological variation and immune priming. In this perspective, I discuss parasite infracommunity interactions and their imprint on host immunity in space and time. I further consider feedbacks from parasite community dynamics within individual hosts on the transmission of disease at higher levels of biological organization and highlight the promise of systems biology approaches, using flour beetles as an example, for studying the role of multiple infections on immunological variation in wild populations.
format	article
author	Ann T. Tate
author_facet	Ann T. Tate
author_sort	Ann T. Tate
title	Role of Multiple Infections on Immunological Variation in Wild Populations
title_short	Role of Multiple Infections on Immunological Variation in Wild Populations
title_full	Role of Multiple Infections on Immunological Variation in Wild Populations
title_fullStr	Role of Multiple Infections on Immunological Variation in Wild Populations
title_full_unstemmed	Role of Multiple Infections on Immunological Variation in Wild Populations
title_sort	role of multiple infections on immunological variation in wild populations
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/4c6f4deb4e4b43dd8fd9a5cae9f133e9
work_keys_str_mv	AT annttate roleofmultipleinfectionsonimmunologicalvariationinwildpopulations
_version_	1718375959314300928

Role of Multiple Infections on Immunological Variation in Wild Populations

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