Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer

Bo Liu, Li Han, Junyan Liu, Shumei Han, Zhen Chen, Lixi Jiang Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, People’s Republic of China Background: Cervical cancer is a major wor...

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Autores principales:	Liu B, Han L, Liu J, Han S, Chen Z, Jiang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Cervical cancer lipid-based prodrug combination therapy solid lipid nanoparticles cell-penetrating peptide Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4c726589e0ef441aa43eff65cfce3a87
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spelling	oai:doaj.org-article:4c726589e0ef441aa43eff65cfce3a872021-12-02T02:56:02ZCo-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer1178-2013https://doaj.org/article/4c726589e0ef441aa43eff65cfce3a872017-01-01T00:00:00Zhttps://www.dovepress.com/co-delivery-of-paclitaxel-and-tos-cisplatin-via-tat-targeted-solid-lip-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bo Liu, Li Han, Junyan Liu, Shumei Han, Zhen Chen, Lixi Jiang Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, People’s Republic of China Background: Cervical cancer is a major world health problem for women. Currently, cancer research focuses on improving therapy for cervical cancer using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers.Purpose: The aim of this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) for co-delivery of paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order to achieve synergistic antitumor activity against cervical cancer.Methods: Lipid prodrug of CDDP (TOS-CDDP) and TAT-containing polyethylene glycol-distearoyl-phosphatidylethanolamine (TAT-PEG-DSPE) were synthesized. TAT PTX/TOS-CDDP SLNs were prepared by emulsification and solvent evaporation method. Physicochemical characteristics of SLNs such as size, morphology, and release profiles were explored. In vitro and in vivo studies were carried out to assess the efficacy of their antitumor activity in target cells.Results: TAT PTX/TOS-CDDP SLNs could be successfully internalized by HeLa cells and showed a synergistic effect in the suppression of cervical tumor cell growth. They exhibited high tumor tissue accumulation, superior antitumor efficiency, and much lower toxicity in vivo.Conclusion: The present study indicates that the co-delivery system provides a promising platform as a combination therapy for the treatment of cervical cancer, and possibly other types of cancer as well. Keywords: cervical cancer, lipid-based prodrug, combination therapy, solid lipid nanoparticles, cell-penetrating peptideLiu BHan LLiu JHan SChen ZJiang LDove Medical PressarticleCervical cancerlipid-based prodrugcombination therapysolid lipid nanoparticlescell-penetrating peptideMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 955-968 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cervical cancer lipid-based prodrug combination therapy solid lipid nanoparticles cell-penetrating peptide Medicine (General) R5-920
spellingShingle	Cervical cancer lipid-based prodrug combination therapy solid lipid nanoparticles cell-penetrating peptide Medicine (General) R5-920 Liu B Han L Liu J Han S Chen Z Jiang L Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
description	Bo Liu, Li Han, Junyan Liu, Shumei Han, Zhen Chen, Lixi Jiang Department of Internal Medicine Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Ji’nan, People’s Republic of China Background: Cervical cancer is a major world health problem for women. Currently, cancer research focuses on improving therapy for cervical cancer using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers.Purpose: The aim of this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) for co-delivery of paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order to achieve synergistic antitumor activity against cervical cancer.Methods: Lipid prodrug of CDDP (TOS-CDDP) and TAT-containing polyethylene glycol-distearoyl-phosphatidylethanolamine (TAT-PEG-DSPE) were synthesized. TAT PTX/TOS-CDDP SLNs were prepared by emulsification and solvent evaporation method. Physicochemical characteristics of SLNs such as size, morphology, and release profiles were explored. In vitro and in vivo studies were carried out to assess the efficacy of their antitumor activity in target cells.Results: TAT PTX/TOS-CDDP SLNs could be successfully internalized by HeLa cells and showed a synergistic effect in the suppression of cervical tumor cell growth. They exhibited high tumor tissue accumulation, superior antitumor efficiency, and much lower toxicity in vivo.Conclusion: The present study indicates that the co-delivery system provides a promising platform as a combination therapy for the treatment of cervical cancer, and possibly other types of cancer as well. Keywords: cervical cancer, lipid-based prodrug, combination therapy, solid lipid nanoparticles, cell-penetrating peptide
format	article
author	Liu B Han L Liu J Han S Chen Z Jiang L
author_facet	Liu B Han L Liu J Han S Chen Z Jiang L
author_sort	Liu B
title	Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
title_short	Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
title_full	Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
title_fullStr	Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
title_full_unstemmed	Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
title_sort	co-delivery of paclitaxel and tos-cisplatin via tat-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4c726589e0ef441aa43eff65cfce3a87
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_version_	1718402040240013312

Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer

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