LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.

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Autores principales:	Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt, Christopher E. Rudd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c73c60958e443bda720387ec3ccab2c
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spelling	oai:doaj.org-article:4c73c60958e443bda720387ec3ccab2c2021-12-02T14:42:09ZLFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation10.1038/ncomms160012041-1723https://doaj.org/article/4c73c60958e443bda720387ec3ccab2c2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms16001https://doaj.org/toc/2041-1723The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.Monika RaabYuning LuKarsten KohlerXin SmithKlaus StrebhardtChristopher E. RuddNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Monika Raab Yuning Lu Karsten Kohler Xin Smith Klaus Strebhardt Christopher E. Rudd LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
description	The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these cells in the context of antigen presentation.
format	article
author	Monika Raab Yuning Lu Karsten Kohler Xin Smith Klaus Strebhardt Christopher E. Rudd
author_facet	Monika Raab Yuning Lu Karsten Kohler Xin Smith Klaus Strebhardt Christopher E. Rudd
author_sort	Monika Raab
title	LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_short	LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_full	LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_fullStr	LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_full_unstemmed	LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation
title_sort	lfa-1 activates focal adhesion kinases fak1/pyk2 to generate lat-grb2-skap1 complexes that terminate t-cell conjugate formation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4c73c60958e443bda720387ec3ccab2c
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LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

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