Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective

Abstract There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tamar B. Wissing, Valentina Bonito, Carlijn V. C. Bouten, Anthal I. P. M. Smits
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/4c770b0f445d4d808139e5c0cffe08f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4c770b0f445d4d808139e5c0cffe08f6
record_format	dspace
spelling	oai:doaj.org-article:4c770b0f445d4d808139e5c0cffe08f62021-12-02T14:18:30ZBiomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective10.1038/s41536-017-0023-22057-3995https://doaj.org/article/4c770b0f445d4d808139e5c0cffe08f62017-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0023-2https://doaj.org/toc/2057-3995Abstract There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.Tamar B. WissingValentina BonitoCarlijn V. C. BoutenAnthal I. P. M. SmitsNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-20 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Tamar B. Wissing Valentina Bonito Carlijn V. C. Bouten Anthal I. P. M. Smits Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
description	Abstract There is a persistent and growing clinical need for readily-available substitutes for heart valves and small-diameter blood vessels. In situ tissue engineering is emerging as a disruptive new technology, providing ready-to-use biodegradable, cell-free constructs which are designed to induce regeneration upon implantation, directly in the functional site. The induced regenerative process hinges around the host response to the implanted biomaterial and the interplay between immune cells, stem/progenitor cell and tissue cells in the microenvironment provided by the scaffold in the hemodynamic environment. Recapitulating the complex tissue microstructure and function of cardiovascular tissues is a highly challenging target. Therein the scaffold plays an instructive role, providing the microenvironment that attracts and harbors host cells, modulating the inflammatory response, and acting as a temporal roadmap for new tissue to be formed. Moreover, the biomechanical loads imposed by the hemodynamic environment play a pivotal role. Here, we provide a multidisciplinary view on in situ cardiovascular tissue engineering using synthetic scaffolds; starting from the state-of-the art, the principles of the biomaterial-driven host response and wound healing and the cellular players involved, toward the impact of the biomechanical, physical, and biochemical microenvironmental cues that are given by the scaffold design. To conclude, we pinpoint and further address the main current challenges for in situ cardiovascular regeneration, namely the achievement of tissue homeostasis, the development of predictive models for long-term performances of the implanted grafts, and the necessity for stratification for successful clinical translation.
format	article
author	Tamar B. Wissing Valentina Bonito Carlijn V. C. Bouten Anthal I. P. M. Smits
author_facet	Tamar B. Wissing Valentina Bonito Carlijn V. C. Bouten Anthal I. P. M. Smits
author_sort	Tamar B. Wissing
title	Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
title_short	Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
title_full	Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
title_fullStr	Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
title_full_unstemmed	Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
title_sort	biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4c770b0f445d4d808139e5c0cffe08f6
work_keys_str_mv	AT tamarbwissing biomaterialdriveninsitucardiovasculartissueengineeringamultidisciplinaryperspective AT valentinabonito biomaterialdriveninsitucardiovasculartissueengineeringamultidisciplinaryperspective AT carlijnvcbouten biomaterialdriveninsitucardiovasculartissueengineeringamultidisciplinaryperspective AT anthalipmsmits biomaterialdriveninsitucardiovasculartissueengineeringamultidisciplinaryperspective
_version_	1718391604235993088

Biomaterial-driven in situ cardiovascular tissue engineering—a multi-disciplinary perspective

Ejemplares similares