Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.

<h4>Background</h4>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an unculturable pathogen with an exceptionally eroded genome. The high level of inactivation of gene function in M. leprae, including many genes in its metabolic pathways, has led to a dependence o...

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Autores principales:	Dong Wang, Ling-Yan Su, A-Mei Zhang, Yu-Ye Li, Xiao-An Li, Ling-Ling Chen, Heng Long, Yong-Gang Yao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c776fc6eefd4c43af0df312445b1c86
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spelling	oai:doaj.org-article:4c776fc6eefd4c43af0df312445b1c862021-11-18T07:15:16ZMitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.1932-620310.1371/journal.pone.0038848https://doaj.org/article/4c776fc6eefd4c43af0df312445b1c862012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22719964/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an unculturable pathogen with an exceptionally eroded genome. The high level of inactivation of gene function in M. leprae, including many genes in its metabolic pathways, has led to a dependence on host energy production and nutritional products. We hypothesized that host cellular powerhouse--the mitochondria--may affect host susceptibility to M. leprae and the onset of clinical leprosy, and this may be reflected by mitochondrial DNA (mtDNA) background and mtDNA copy number.<h4>Methods</h4>We analyzed the mtDNA sequence variation of 534 leprosy patients and 850 matched controls from Yunnan Province and classified each subject by haplogroup. mtDNA copy number, taken to be proportional to mtDNA content, was measured in a subset of these subjects (296 patients and 231 controls) and 12 leprosy patients upon diagnosis.<h4>Results</h4>Comparison of matrilineal components of the case and control populations revealed no significant difference. However, measurement of mtDNA copy number showed that lepromatous leprosy patients had a significantly higher mtDNA content than controls (P = 0.008). Past medical treatments had no effect on the alteration of mtDNA copy number.<h4>Conclusions</h4>Our results suggested that mtDNA content, but not haplogroup, affects leprosy and this influence is limited to the clinical subtype of lepromatous leprosy.Dong WangLing-Yan SuA-Mei ZhangYu-Ye LiXiao-An LiLing-Ling ChenHeng LongYong-Gang YaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38848 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Wang Ling-Yan Su A-Mei Zhang Yu-Ye Li Xiao-An Li Ling-Ling Chen Heng Long Yong-Gang Yao Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.
description	<h4>Background</h4>Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an unculturable pathogen with an exceptionally eroded genome. The high level of inactivation of gene function in M. leprae, including many genes in its metabolic pathways, has led to a dependence on host energy production and nutritional products. We hypothesized that host cellular powerhouse--the mitochondria--may affect host susceptibility to M. leprae and the onset of clinical leprosy, and this may be reflected by mitochondrial DNA (mtDNA) background and mtDNA copy number.<h4>Methods</h4>We analyzed the mtDNA sequence variation of 534 leprosy patients and 850 matched controls from Yunnan Province and classified each subject by haplogroup. mtDNA copy number, taken to be proportional to mtDNA content, was measured in a subset of these subjects (296 patients and 231 controls) and 12 leprosy patients upon diagnosis.<h4>Results</h4>Comparison of matrilineal components of the case and control populations revealed no significant difference. However, measurement of mtDNA copy number showed that lepromatous leprosy patients had a significantly higher mtDNA content than controls (P = 0.008). Past medical treatments had no effect on the alteration of mtDNA copy number.<h4>Conclusions</h4>Our results suggested that mtDNA content, but not haplogroup, affects leprosy and this influence is limited to the clinical subtype of lepromatous leprosy.
format	article
author	Dong Wang Ling-Yan Su A-Mei Zhang Yu-Ye Li Xiao-An Li Ling-Ling Chen Heng Long Yong-Gang Yao
author_facet	Dong Wang Ling-Yan Su A-Mei Zhang Yu-Ye Li Xiao-An Li Ling-Ling Chen Heng Long Yong-Gang Yao
author_sort	Dong Wang
title	Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.
title_short	Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.
title_full	Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.
title_fullStr	Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.
title_full_unstemmed	Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.
title_sort	mitochondrial dna copy number, but not haplogroup, confers a genetic susceptibility to leprosy in han chinese from southwest china.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4c776fc6eefd4c43af0df312445b1c86
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Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China.

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