Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.

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Autores principales:	Iosif Pediaditakis, Konstantia R. Kodella, Dimitris V. Manatakis, Christopher Y. Le, Chris D. Hinojosa, William Tien-Street, Elias S. Manolakos, Kostas Vekrellis, Geraldine A. Hamilton, Lorna Ewart, Lee L. Rubin, Katia Karalis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c79c98786c94d82a820ab3e121c9759
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spelling	oai:doaj.org-article:4c79c98786c94d82a820ab3e121c97592021-12-02T16:56:43ZModeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption10.1038/s41467-021-26066-52041-1723https://doaj.org/article/4c79c98786c94d82a820ab3e121c97592021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26066-5https://doaj.org/toc/2041-1723Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.Iosif PediaditakisKonstantia R. KodellaDimitris V. ManatakisChristopher Y. LeChris D. HinojosaWilliam Tien-StreetElias S. ManolakosKostas VekrellisGeraldine A. HamiltonLorna EwartLee L. RubinKatia KaralisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Iosif Pediaditakis Konstantia R. Kodella Dimitris V. Manatakis Christopher Y. Le Chris D. Hinojosa William Tien-Street Elias S. Manolakos Kostas Vekrellis Geraldine A. Hamilton Lorna Ewart Lee L. Rubin Katia Karalis Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
description	Cellular models of organs have been used to investigate mechanisms of disease. Here the authors generate a human alpha synuclein-induced brain-chip model that recapitulates blood-brain barrier dysfunction, as a potential testing platform for novel therapeutics in Parkinson’s disease.
format	article
author	Iosif Pediaditakis Konstantia R. Kodella Dimitris V. Manatakis Christopher Y. Le Chris D. Hinojosa William Tien-Street Elias S. Manolakos Kostas Vekrellis Geraldine A. Hamilton Lorna Ewart Lee L. Rubin Katia Karalis
author_facet	Iosif Pediaditakis Konstantia R. Kodella Dimitris V. Manatakis Christopher Y. Le Chris D. Hinojosa William Tien-Street Elias S. Manolakos Kostas Vekrellis Geraldine A. Hamilton Lorna Ewart Lee L. Rubin Katia Karalis
author_sort	Iosif Pediaditakis
title	Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
title_short	Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
title_full	Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
title_fullStr	Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
title_full_unstemmed	Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
title_sort	modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c79c98786c94d82a820ab3e121c9759
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Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

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