Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis

Abstract Postoperative pancreatic fistula (POPF) is a common complication following distal pancreatectomy (DP). However, the risk factors of this complication in patients after DP still remain controversial. The aim of our study is to estimate the association between potential risk factors and POPF....

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Autores principales:	Yun-Peng Peng, Xiao-Le Zhu, Ling-Di Yin, Yi Zhu, Ji-Shu Wei, Jun-Li Wu, Yi Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c7a32431c754e91a4b593153698f845
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spelling	oai:doaj.org-article:4c7a32431c754e91a4b593153698f8452021-12-02T11:40:53ZRisk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis10.1038/s41598-017-00311-82045-2322https://doaj.org/article/4c7a32431c754e91a4b593153698f8452017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00311-8https://doaj.org/toc/2045-2322Abstract Postoperative pancreatic fistula (POPF) is a common complication following distal pancreatectomy (DP). However, the risk factors of this complication in patients after DP still remain controversial. The aim of our study is to estimate the association between potential risk factors and POPF. Relevant articles published up to June 21, 2016 were identified via PubMed, EMBASE, Web of Science, and The Cochrane Library. Studies that examined the risk factors of POPF following DP were enrolled. 20 articles (2070 patients) were finally included in this study. The pooled data suggested that patients with soft pancreas, higher Body Mass Index (BMI), blood transfusion, elevated intraoperative blood loss, and longer operative time had a decreased risk for POPF. However, age, gender, malignant pathology, types of stump closure, octreotide therapy, history of diabetes and chronic pancreatitis, splenectomy, multiorgan resection, main duct ligation, preoperative serum albumin levels, PGA felt wrapping, and extended lymphadenectomy could not be regarded as risk factors for POPF. Our analytic data demonstrated that pancreas texture, BMI, blood transfusion, intraoperative blood loss, and operative time were clinical predictor for POPF. This study may assist surgeons to screen patients with high risk of POPF and select appropriate treatment measures.Yun-Peng PengXiao-Le ZhuLing-Di YinYi ZhuJi-Shu WeiJun-Li WuYi MiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun-Peng Peng Xiao-Le Zhu Ling-Di Yin Yi Zhu Ji-Shu Wei Jun-Li Wu Yi Miao Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
description	Abstract Postoperative pancreatic fistula (POPF) is a common complication following distal pancreatectomy (DP). However, the risk factors of this complication in patients after DP still remain controversial. The aim of our study is to estimate the association between potential risk factors and POPF. Relevant articles published up to June 21, 2016 were identified via PubMed, EMBASE, Web of Science, and The Cochrane Library. Studies that examined the risk factors of POPF following DP were enrolled. 20 articles (2070 patients) were finally included in this study. The pooled data suggested that patients with soft pancreas, higher Body Mass Index (BMI), blood transfusion, elevated intraoperative blood loss, and longer operative time had a decreased risk for POPF. However, age, gender, malignant pathology, types of stump closure, octreotide therapy, history of diabetes and chronic pancreatitis, splenectomy, multiorgan resection, main duct ligation, preoperative serum albumin levels, PGA felt wrapping, and extended lymphadenectomy could not be regarded as risk factors for POPF. Our analytic data demonstrated that pancreas texture, BMI, blood transfusion, intraoperative blood loss, and operative time were clinical predictor for POPF. This study may assist surgeons to screen patients with high risk of POPF and select appropriate treatment measures.
format	article
author	Yun-Peng Peng Xiao-Le Zhu Ling-Di Yin Yi Zhu Ji-Shu Wei Jun-Li Wu Yi Miao
author_facet	Yun-Peng Peng Xiao-Le Zhu Ling-Di Yin Yi Zhu Ji-Shu Wei Jun-Li Wu Yi Miao
author_sort	Yun-Peng Peng
title	Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_short	Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_full	Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_fullStr	Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_full_unstemmed	Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_sort	risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4c7a32431c754e91a4b593153698f845
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Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis

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