Сytokine markers for different variants of sclerotic lichen in women

Our work was aimed for studying the role of systemic of IL-23 and IL-20 levels in different clinical variants of sclerotic lichen in women. The study was based on results of clinical data (anamnesis, examination, palpation, vulvoscopy) and immunological studies (determination of IL-20 and IL-23 cyto...

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Autores principales:	E. V. Kolesnikova, A. V. Zharov, I. A. Kharitonova, Yu. S. Mizina, S. V. Fedak
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2020
Materias:	сytokines vulva sclerotic lihen atrophic lihen interleukins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4c7b9dbb4d024ed79b733e45261d77c2
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spelling	oai:doaj.org-article:4c7b9dbb4d024ed79b733e45261d77c22021-11-18T08:03:49ZСytokine markers for different variants of sclerotic lichen in women1563-06252313-741X10.15789/1563-0625-CMF-1864https://doaj.org/article/4c7b9dbb4d024ed79b733e45261d77c22020-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1864https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOur work was aimed for studying the role of systemic of IL-23 and IL-20 levels in different clinical variants of sclerotic lichen in women. The study was based on results of clinical data (anamnesis, examination, palpation, vulvoscopy) and immunological studies (determination of IL-20 and IL-23 cytokines in peripheral blood) in the patients with sclerotic lichen (114 patients aged 42.5±15.1 years). Group I included patients with atrophic variant of sclerotic lichen (n = 58); group II, with sclerotic variant of sclerotic lichen (n = 34). Group III included women with a sclero-atrophic variant of this disorder (n = 22). The control group consisted of conditionally healthy women without present, or previously documented vulvar pathology (30 persons). Criteria for inclusion were as follows: women 20 to 60 years old, the presence of a benign vulvar disease, absence of treatment with immunotropic drugs over past year. Exclusion criteria: presence of viral infection (HPV, HSV), detection of STI, presence of acute inflammatory process (including vulvitis and vaginitis), cancer diagnosis, symptoms of autoimmune disorders, pregnancy, and the patient’s reluctance to participate in the study.Predominant increase of IL-23 was revealed in all clinical groups of the examined patients, the most pronounced increase (2.7 times) was in severe sclerotic lichen (p < 0.0001). IL-23 concentration in the 2nd clinical group corresponded to the reference age-matched values. There was a significant increase in the blood content of IL-20 in subgroup 2.2 of the patients with sclerotic lichen (p < 0.0001), as well as in patients from group 3 with a mixed clinical course of its disorder (p < 0.0001). Meanwhile, the absence of pronounced vulvar tissue sclerosis in sclerotic variant of sclerotic lichen (subgroup 2.1) was accompanied only by a tendency for increased IL-20 concentration (p = 0.502), and only a trend for decrease in atrophic variant of sclerotic lichen (p = 0.288). In general, analysis of these data presumes a significant role of IL-20 and IL-23 in pathogenesis of sclerotic lichen in women. The cytokine assays in various clinical variants of this vulvar disorder may provide additional differential diagnostics (IL-20), and to assess severity of atrophic and sclerotic changes in vulvar tissues (IL-23) in women with sclerotic lichen.E. V. KolesnikovaA. V. ZharovI. A. KharitonovaYu. S. MizinaS. V. FedakSPb RAACIarticleсytokinesvulvasclerotic lihenatrophic liheninterleukinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 3, Pp 551-556 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	сytokines vulva sclerotic lihen atrophic lihen interleukins Immunologic diseases. Allergy RC581-607
spellingShingle	сytokines vulva sclerotic lihen atrophic lihen interleukins Immunologic diseases. Allergy RC581-607 E. V. Kolesnikova A. V. Zharov I. A. Kharitonova Yu. S. Mizina S. V. Fedak Сytokine markers for different variants of sclerotic lichen in women
description	Our work was aimed for studying the role of systemic of IL-23 and IL-20 levels in different clinical variants of sclerotic lichen in women. The study was based on results of clinical data (anamnesis, examination, palpation, vulvoscopy) and immunological studies (determination of IL-20 and IL-23 cytokines in peripheral blood) in the patients with sclerotic lichen (114 patients aged 42.5±15.1 years). Group I included patients with atrophic variant of sclerotic lichen (n = 58); group II, with sclerotic variant of sclerotic lichen (n = 34). Group III included women with a sclero-atrophic variant of this disorder (n = 22). The control group consisted of conditionally healthy women without present, or previously documented vulvar pathology (30 persons). Criteria for inclusion were as follows: women 20 to 60 years old, the presence of a benign vulvar disease, absence of treatment with immunotropic drugs over past year. Exclusion criteria: presence of viral infection (HPV, HSV), detection of STI, presence of acute inflammatory process (including vulvitis and vaginitis), cancer diagnosis, symptoms of autoimmune disorders, pregnancy, and the patient’s reluctance to participate in the study.Predominant increase of IL-23 was revealed in all clinical groups of the examined patients, the most pronounced increase (2.7 times) was in severe sclerotic lichen (p < 0.0001). IL-23 concentration in the 2nd clinical group corresponded to the reference age-matched values. There was a significant increase in the blood content of IL-20 in subgroup 2.2 of the patients with sclerotic lichen (p < 0.0001), as well as in patients from group 3 with a mixed clinical course of its disorder (p < 0.0001). Meanwhile, the absence of pronounced vulvar tissue sclerosis in sclerotic variant of sclerotic lichen (subgroup 2.1) was accompanied only by a tendency for increased IL-20 concentration (p = 0.502), and only a trend for decrease in atrophic variant of sclerotic lichen (p = 0.288). In general, analysis of these data presumes a significant role of IL-20 and IL-23 in pathogenesis of sclerotic lichen in women. The cytokine assays in various clinical variants of this vulvar disorder may provide additional differential diagnostics (IL-20), and to assess severity of atrophic and sclerotic changes in vulvar tissues (IL-23) in women with sclerotic lichen.
format	article
author	E. V. Kolesnikova A. V. Zharov I. A. Kharitonova Yu. S. Mizina S. V. Fedak
author_facet	E. V. Kolesnikova A. V. Zharov I. A. Kharitonova Yu. S. Mizina S. V. Fedak
author_sort	E. V. Kolesnikova
title	Сytokine markers for different variants of sclerotic lichen in women
title_short	Сytokine markers for different variants of sclerotic lichen in women
title_full	Сytokine markers for different variants of sclerotic lichen in women
title_fullStr	Сytokine markers for different variants of sclerotic lichen in women
title_full_unstemmed	Сytokine markers for different variants of sclerotic lichen in women
title_sort	сytokine markers for different variants of sclerotic lichen in women
publisher	SPb RAACI
publishDate	2020
url	https://doaj.org/article/4c7b9dbb4d024ed79b733e45261d77c2
work_keys_str_mv	AT evkolesnikova sytokinemarkersfordifferentvariantsofscleroticlicheninwomen AT avzharov sytokinemarkersfordifferentvariantsofscleroticlicheninwomen AT iakharitonova sytokinemarkersfordifferentvariantsofscleroticlicheninwomen AT yusmizina sytokinemarkersfordifferentvariantsofscleroticlicheninwomen AT svfedak sytokinemarkersfordifferentvariantsofscleroticlicheninwomen
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Сytokine markers for different variants of sclerotic lichen in women

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