Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model

Abstract Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus inf...

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Autores principales:	Wei Yu, Di Yao, Simiao Yu, Xintong Wang, Xiaoting Li, Mengyao Wang, Shuo Liu, Zhenyue Feng, Xiaoting Chen, Wanyu Li, Lizi Wang, Wei Liu, Jinzhu Ma, Liquan Yu, Chunyu Tong, Baifen Song, Yudong Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c7bd6bea6e3493e96895eac3abd5b03
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spelling	oai:doaj.org-article:4c7bd6bea6e3493e96895eac3abd5b032021-12-02T15:08:23ZProtective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model10.1038/s41598-018-22044-y2045-2322https://doaj.org/article/4c7bd6bea6e3493e96895eac3abd5b032018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-22044-yhttps://doaj.org/toc/2045-2322Abstract Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus infections is increasingly encouraged and supported. S. aureus manganese transport protein C (MntC), which is a highly-conserved cell surface protein, can elicit protective immunity against S. aureus and Staphylococcus epidermidis. In this study, we evaluated the humoral immune response and CD4+ T cell-mediated immune responses in a mouse peritonitis model. The results showed that MntC-specific antibodies conferred an essential protection for mice to reduce invasion of S. aureus, which was corroborated via the opsonophagocytic killing assay and passive immunization experiment in mice, and moreover MntC-induced Th17 played a remarkable part in preventing S. aureus infection since the MntC-induced protective immunity decreased after neutralization of IL-17 by antibody in vivo and the Th17 adoptive transferred-mice could partly resist S. aureus challenge. In conclusion, we considered that the MntC-specific antibodies and MntC-specific Th17 cells play cooperative roles in the prevention of S. aureus infection.Wei YuDi YaoSimiao YuXintong WangXiaoting LiMengyao WangShuo LiuZhenyue FengXiaoting ChenWanyu LiLizi WangWei LiuJinzhu MaLiquan YuChunyu TongBaifen SongYudong CuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Yu Di Yao Simiao Yu Xintong Wang Xiaoting Li Mengyao Wang Shuo Liu Zhenyue Feng Xiaoting Chen Wanyu Li Lizi Wang Wei Liu Jinzhu Ma Liquan Yu Chunyu Tong Baifen Song Yudong Cui Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model
description	Abstract Staphylococcus aureus can cause different types of diseases from mild skin infections to life-threatening sepsis worldwide. Owing to the emergence and transmission of multidrug-resistant strains, developing an impactful immunotherapy especially vaccine control approach against S. aureus infections is increasingly encouraged and supported. S. aureus manganese transport protein C (MntC), which is a highly-conserved cell surface protein, can elicit protective immunity against S. aureus and Staphylococcus epidermidis. In this study, we evaluated the humoral immune response and CD4+ T cell-mediated immune responses in a mouse peritonitis model. The results showed that MntC-specific antibodies conferred an essential protection for mice to reduce invasion of S. aureus, which was corroborated via the opsonophagocytic killing assay and passive immunization experiment in mice, and moreover MntC-induced Th17 played a remarkable part in preventing S. aureus infection since the MntC-induced protective immunity decreased after neutralization of IL-17 by antibody in vivo and the Th17 adoptive transferred-mice could partly resist S. aureus challenge. In conclusion, we considered that the MntC-specific antibodies and MntC-specific Th17 cells play cooperative roles in the prevention of S. aureus infection.
format	article
author	Wei Yu Di Yao Simiao Yu Xintong Wang Xiaoting Li Mengyao Wang Shuo Liu Zhenyue Feng Xiaoting Chen Wanyu Li Lizi Wang Wei Liu Jinzhu Ma Liquan Yu Chunyu Tong Baifen Song Yudong Cui
author_facet	Wei Yu Di Yao Simiao Yu Xintong Wang Xiaoting Li Mengyao Wang Shuo Liu Zhenyue Feng Xiaoting Chen Wanyu Li Lizi Wang Wei Liu Jinzhu Ma Liquan Yu Chunyu Tong Baifen Song Yudong Cui
author_sort	Wei Yu
title	Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model
title_short	Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model
title_full	Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model
title_fullStr	Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model
title_full_unstemmed	Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model
title_sort	protective humoral and cd4+ t cellular immune responses of staphylococcus aureus vaccine mntc in a murine peritonitis model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4c7bd6bea6e3493e96895eac3abd5b03
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Protective humoral and CD4+ T cellular immune responses of Staphylococcus aureus vaccine MntC in a murine peritonitis model

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