Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects

Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects

Abstract Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson’s disease (PD). However, how endogenous GDNF influences dopamine system function and an...

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Autores principales: Kärt Mätlik, Vootele Võikar, Carolina Vilenius, Natalia Kulesskaya, Jaan-Olle Andressoo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/4c8060365899450983ac1b9eea80ab2e
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