Cross sectional study of the clinical characteristics of French primary care patients with COVID-19

Abstract The early identification of patients suffering from SARS-CoV-2 infection in primary care is of outmost importance in the current pandemic. The objective of this study was to describe the clinical characteristics of primary care patients who tested positive for SARS-CoV-2. We conducted a cro...

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Autores principales:	Paul Sebo, Benoit Tudrej, Julie Lourdaux, Clara Cuzin, Martin Floquet, Dagmar M. Haller, Hubert Maisonneuve
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c831fea17774c339e29d2daa204e50a
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spelling	oai:doaj.org-article:4c831fea17774c339e29d2daa204e50a2021-12-02T17:23:16ZCross sectional study of the clinical characteristics of French primary care patients with COVID-1910.1038/s41598-021-91685-32045-2322https://doaj.org/article/4c831fea17774c339e29d2daa204e50a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91685-3https://doaj.org/toc/2045-2322Abstract The early identification of patients suffering from SARS-CoV-2 infection in primary care is of outmost importance in the current pandemic. The objective of this study was to describe the clinical characteristics of primary care patients who tested positive for SARS-CoV-2. We conducted a cross-sectional study between March 24 and May 7, 2020, involving consecutive patients undergoing RT-PCR testing in two community-based laboratories in Lyon (France) for a suspicion of COVID-19. We examined the association between symptoms and a positive test using univariable and multivariable logistic regression, adjusted for clustering within laboratories, and calculated the diagnostic performance of these symptoms. Of the 1561 patients tested, 1543 patients (99%) agreed to participate. Among them, 253 were positive for SARS-CoV-2 (16%). The three most frequently reported ‘ear-nose-throat’ and non-‘ear-nose-throat’ symptoms in patients who tested positive were dry throat (42%), loss of smell (36%) and loss of taste (31%), respectively fever (58%), cough (52%) and headache (45%). In multivariable analyses, loss of taste (OR 3.8 [95% CI 3.3–4.4], p-value < 0.001), loss of smell (OR 3.0 [95% CI 1.9–4.8], p < 0.001), muscle pain (OR 1.6 [95% CI 1.2–2.0], p = 0.001) and dry nose (OR 1.3 [95% CI 1.1–1.6], p = 0.01) were significantly associated with a positive result. In contrast, sore throat (OR 0.6 [95% CI 0.4–0.8], p = 0.003), stuffy nose (OR 0.6 [95% CI 0.6–0.7], p < 0.001), diarrhea (OR 0.6 [95% CI 0.5–0.6], p < 0.001) and dyspnea (OR 0.5 [95% CI 0.3–0.7], p < 0.001) were inversely associated with a positive test. The combination of loss of taste or smell had the highest diagnostic performance (OR 6.7 [95% CI 5.9–7.5], sensitivity 44.7% [95% CI 38.4–51.0], specificity 90.8% [95% CI 89.1–92.3]). No other combination of symptoms had a higher performance. Our data could contribute to the triage and early identification of new clusters of cases.Paul SeboBenoit TudrejJulie LourdauxClara CuzinMartin FloquetDagmar M. HallerHubert MaisonneuveNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paul Sebo Benoit Tudrej Julie Lourdaux Clara Cuzin Martin Floquet Dagmar M. Haller Hubert Maisonneuve Cross sectional study of the clinical characteristics of French primary care patients with COVID-19
description	Abstract The early identification of patients suffering from SARS-CoV-2 infection in primary care is of outmost importance in the current pandemic. The objective of this study was to describe the clinical characteristics of primary care patients who tested positive for SARS-CoV-2. We conducted a cross-sectional study between March 24 and May 7, 2020, involving consecutive patients undergoing RT-PCR testing in two community-based laboratories in Lyon (France) for a suspicion of COVID-19. We examined the association between symptoms and a positive test using univariable and multivariable logistic regression, adjusted for clustering within laboratories, and calculated the diagnostic performance of these symptoms. Of the 1561 patients tested, 1543 patients (99%) agreed to participate. Among them, 253 were positive for SARS-CoV-2 (16%). The three most frequently reported ‘ear-nose-throat’ and non-‘ear-nose-throat’ symptoms in patients who tested positive were dry throat (42%), loss of smell (36%) and loss of taste (31%), respectively fever (58%), cough (52%) and headache (45%). In multivariable analyses, loss of taste (OR 3.8 [95% CI 3.3–4.4], p-value < 0.001), loss of smell (OR 3.0 [95% CI 1.9–4.8], p < 0.001), muscle pain (OR 1.6 [95% CI 1.2–2.0], p = 0.001) and dry nose (OR 1.3 [95% CI 1.1–1.6], p = 0.01) were significantly associated with a positive result. In contrast, sore throat (OR 0.6 [95% CI 0.4–0.8], p = 0.003), stuffy nose (OR 0.6 [95% CI 0.6–0.7], p < 0.001), diarrhea (OR 0.6 [95% CI 0.5–0.6], p < 0.001) and dyspnea (OR 0.5 [95% CI 0.3–0.7], p < 0.001) were inversely associated with a positive test. The combination of loss of taste or smell had the highest diagnostic performance (OR 6.7 [95% CI 5.9–7.5], sensitivity 44.7% [95% CI 38.4–51.0], specificity 90.8% [95% CI 89.1–92.3]). No other combination of symptoms had a higher performance. Our data could contribute to the triage and early identification of new clusters of cases.
format	article
author	Paul Sebo Benoit Tudrej Julie Lourdaux Clara Cuzin Martin Floquet Dagmar M. Haller Hubert Maisonneuve
author_facet	Paul Sebo Benoit Tudrej Julie Lourdaux Clara Cuzin Martin Floquet Dagmar M. Haller Hubert Maisonneuve
author_sort	Paul Sebo
title	Cross sectional study of the clinical characteristics of French primary care patients with COVID-19
title_short	Cross sectional study of the clinical characteristics of French primary care patients with COVID-19
title_full	Cross sectional study of the clinical characteristics of French primary care patients with COVID-19
title_fullStr	Cross sectional study of the clinical characteristics of French primary care patients with COVID-19
title_full_unstemmed	Cross sectional study of the clinical characteristics of French primary care patients with COVID-19
title_sort	cross sectional study of the clinical characteristics of french primary care patients with covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c831fea17774c339e29d2daa204e50a
work_keys_str_mv	AT paulsebo crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19 AT benoittudrej crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19 AT julielourdaux crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19 AT claracuzin crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19 AT martinfloquet crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19 AT dagmarmhaller crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19 AT hubertmaisonneuve crosssectionalstudyoftheclinicalcharacteristicsoffrenchprimarycarepatientswithcovid19
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Cross sectional study of the clinical characteristics of French primary care patients with COVID-19

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