AMPA receptors in the synapse turnover by monomer diffusion

The mechanisms regulating the turnover of the AMPARs in the synapse, which is critically important to sustain basic synaptic activity, remains unclear. In this study, authors used single-molecule imaging techniques to demonstrate that AMPAR tetramers are not stable entities and readily fall apart to...

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Auteurs principaux:	Jyoji Morise, Kenichi G. N. Suzuki, Ayaka Kitagawa, Yoshihiko Wakazono, Kogo Takamiya, Taka A. Tsunoyama, Yuri L. Nemoto, Hiromu Takematsu, Akihiro Kusumi, Shogo Oka
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4c8417a27ae841158a4dea96ecd16b40
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spelling	oai:doaj.org-article:4c8417a27ae841158a4dea96ecd16b402021-12-02T14:35:56ZAMPA receptors in the synapse turnover by monomer diffusion10.1038/s41467-019-13229-82041-1723https://doaj.org/article/4c8417a27ae841158a4dea96ecd16b402019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13229-8https://doaj.org/toc/2041-1723The mechanisms regulating the turnover of the AMPARs in the synapse, which is critically important to sustain basic synaptic activity, remains unclear. In this study, authors used single-molecule imaging techniques to demonstrate that AMPAR tetramers are not stable entities and readily fall apart to dimers and monomers that could reform to tetramers at the synapse, and that rapidly diffusing monomers in the plasma membrane are primarily responsible for the AMPAR turnover in the synapse.Jyoji MoriseKenichi G. N. SuzukiAyaka KitagawaYoshihiko WakazonoKogo TakamiyaTaka A. TsunoyamaYuri L. NemotoHiromu TakematsuAkihiro KusumiShogo OkaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jyoji Morise Kenichi G. N. Suzuki Ayaka Kitagawa Yoshihiko Wakazono Kogo Takamiya Taka A. Tsunoyama Yuri L. Nemoto Hiromu Takematsu Akihiro Kusumi Shogo Oka AMPA receptors in the synapse turnover by monomer diffusion
description	The mechanisms regulating the turnover of the AMPARs in the synapse, which is critically important to sustain basic synaptic activity, remains unclear. In this study, authors used single-molecule imaging techniques to demonstrate that AMPAR tetramers are not stable entities and readily fall apart to dimers and monomers that could reform to tetramers at the synapse, and that rapidly diffusing monomers in the plasma membrane are primarily responsible for the AMPAR turnover in the synapse.
format	article
author	Jyoji Morise Kenichi G. N. Suzuki Ayaka Kitagawa Yoshihiko Wakazono Kogo Takamiya Taka A. Tsunoyama Yuri L. Nemoto Hiromu Takematsu Akihiro Kusumi Shogo Oka
author_facet	Jyoji Morise Kenichi G. N. Suzuki Ayaka Kitagawa Yoshihiko Wakazono Kogo Takamiya Taka A. Tsunoyama Yuri L. Nemoto Hiromu Takematsu Akihiro Kusumi Shogo Oka
author_sort	Jyoji Morise
title	AMPA receptors in the synapse turnover by monomer diffusion
title_short	AMPA receptors in the synapse turnover by monomer diffusion
title_full	AMPA receptors in the synapse turnover by monomer diffusion
title_fullStr	AMPA receptors in the synapse turnover by monomer diffusion
title_full_unstemmed	AMPA receptors in the synapse turnover by monomer diffusion
title_sort	ampa receptors in the synapse turnover by monomer diffusion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4c8417a27ae841158a4dea96ecd16b40
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AMPA receptors in the synapse turnover by monomer diffusion

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