Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?

The involvement of the human microbiome is crucial for different host functions such as protection, metabolism, reproduction, and especially immunity. However, both endogenous and exogenous factors can affect the balance of the microbiota, creating a state of dysbiosis, which can start various gastr...

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Autores principales:	Amedeo Amedei, Clemente Capasso, Giulia Nannini, Claudiu T. Supuran
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/4c87099e351142e3b1959c1554c4d53e
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spelling	oai:doaj.org-article:4c87099e351142e3b1959c1554c4d53e2021-11-22T01:10:48ZMicrobiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?1466-186110.1155/2021/6926082https://doaj.org/article/4c87099e351142e3b1959c1554c4d53e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6926082https://doaj.org/toc/1466-1861The involvement of the human microbiome is crucial for different host functions such as protection, metabolism, reproduction, and especially immunity. However, both endogenous and exogenous factors can affect the balance of the microbiota, creating a state of dysbiosis, which can start various gastrointestinal or systemic diseases. The challenge of future medicine is to remodel the intestinal microbiota to bring it back to healthy equilibrium (eubiosis) and, thus, counteract its negative role in the diseases’ onset. The shaping of the microbiota is currently practiced in different ways ranging from diet (or use of prebiotics, probiotics, and synbiotics) to phage therapy and antibiotics, including microbiota fecal transplantation. Furthermore, because microbiota modulation is a capillary process, and because many microbiota bacteria (both beneficial and pathogenic) have carbonic anhydrases (specifically the four classes α, β, γ, and ι), we believe that the use of CA inhibitors and activators can open up new therapeutic strategies for many diseases associated with microbial dysbiosis, such as the various gastrointestinal disorders and the same colorectal cancer.Amedeo AmedeiClemente CapassoGiulia NanniniClaudiu T. SupuranHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Amedeo Amedei Clemente Capasso Giulia Nannini Claudiu T. Supuran Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
description	The involvement of the human microbiome is crucial for different host functions such as protection, metabolism, reproduction, and especially immunity. However, both endogenous and exogenous factors can affect the balance of the microbiota, creating a state of dysbiosis, which can start various gastrointestinal or systemic diseases. The challenge of future medicine is to remodel the intestinal microbiota to bring it back to healthy equilibrium (eubiosis) and, thus, counteract its negative role in the diseases’ onset. The shaping of the microbiota is currently practiced in different ways ranging from diet (or use of prebiotics, probiotics, and synbiotics) to phage therapy and antibiotics, including microbiota fecal transplantation. Furthermore, because microbiota modulation is a capillary process, and because many microbiota bacteria (both beneficial and pathogenic) have carbonic anhydrases (specifically the four classes α, β, γ, and ι), we believe that the use of CA inhibitors and activators can open up new therapeutic strategies for many diseases associated with microbial dysbiosis, such as the various gastrointestinal disorders and the same colorectal cancer.
format	article
author	Amedeo Amedei Clemente Capasso Giulia Nannini Claudiu T. Supuran
author_facet	Amedeo Amedei Clemente Capasso Giulia Nannini Claudiu T. Supuran
author_sort	Amedeo Amedei
title	Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
title_short	Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
title_full	Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
title_fullStr	Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
title_full_unstemmed	Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
title_sort	microbiota, bacterial carbonic anhydrases, and modulators of their activity: links to human diseases?
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/4c87099e351142e3b1959c1554c4d53e
work_keys_str_mv	AT amedeoamedei microbiotabacterialcarbonicanhydrasesandmodulatorsoftheiractivitylinkstohumandiseases AT clementecapasso microbiotabacterialcarbonicanhydrasesandmodulatorsoftheiractivitylinkstohumandiseases AT giulianannini microbiotabacterialcarbonicanhydrasesandmodulatorsoftheiractivitylinkstohumandiseases AT claudiutsupuran microbiotabacterialcarbonicanhydrasesandmodulatorsoftheiractivitylinkstohumandiseases
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Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?

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