Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice

Objectives: To investigate how PM2.5 exposure affects the microstructure, metabolites or functions of the visual system. Methods: C57BL/6J mice were randomly assigned to groups exposed to the filtered air (the control group) or the concentrated ambient PM2.5 (the PM2.5 group). Visual evoked potentia...

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Autores principales:	Linying Guo, He Wang, Ji Zhou, Weijun Tang, Rong Wang, Zebin Xiao, Lingjie Wu, Jie Wang, Liping Li, Yuan Lei, Xinghuai Sun, Zuohua Tang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diffusion tensor imaging PM2.5 exposure Proton magnetic resonance spectroscopy Resting state functional MRI Visual electrophysiology Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/4c8e2814a6514118ac9ab6aeb88d0885
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spelling	oai:doaj.org-article:4c8e2814a6514118ac9ab6aeb88d08852021-11-06T04:13:59ZMagnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice0147-651310.1016/j.ecoenv.2021.112866https://doaj.org/article/4c8e2814a6514118ac9ab6aeb88d08852021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321009787https://doaj.org/toc/0147-6513Objectives: To investigate how PM2.5 exposure affects the microstructure, metabolites or functions of the visual system. Methods: C57BL/6J mice were randomly assigned to groups exposed to the filtered air (the control group) or the concentrated ambient PM2.5 (the PM2.5 group). Visual evoked potentials (VEP), electroretinograms (ERG), diffusion tensor imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS) and resting-state functional MRI (rsfMRI) were performed. Parameters were obtained and compared between the two groups, including latencies and amplitudes of the P1 wave, N1 wave and P2 wave from VEP, latencies and amplitudes of the a wave and b wave from ERG, fractional anisotropy (FA), mean diffusion (MD), axial diffusivity (AD) and radial diffusivity (RD) from DTI, visual cortex (VC) metabolites from 1H-MRS, and regional homogeneity (ReHo) from rsfMRI. Results: Compared with the values of the control group, the PM2.5 group showed a prolonged N1 latency (43.11 ± 7.94 ms vs. 38.75 ± 4.60 ms) and lowered P1 amplitude (5.62 ± 4.38 μV vs. 8.56 ± 5.92 μV) on VEP (all p < 0.05). On ERG, the amplitude of the a wave was lowered (− 91.39 ± 56.29 μV vs. − 138.68 ± 89.05 μV), the amplitude of the b wave was lowered (194.38 ± 126.27 μV vs. 284.72 ± 170.99 μV), and the latency of the b wave was prolonged (37.78 ± 10.72 ms vs. 33.01 ± 4.34 ms) than the values of the control group (all p < 0.05). DTI indicated FA increase in the bilateral piriform cortex (Pir), FA decrease in the bilateral somatosensory cortex (S) and the bilateral striatum (Stri), AD decrease in the bilateral VC, the right S and the bilateral Pir, MD decrease in the bilateral Pir, and RD decrease in the bilateral Pir in the PM2.5 mice (all p < 0.05, Alphasim corrected). 1H-MRS showed Glutamate (Glu) increase and Phosphocholine (PCh) increase in the VC of the PM2.5 group than those of the control group (PCh 1.63 ± 0.25 vs. 1.50 ± 0.25; PCh/total creatine(tCr) 0.19 ± 0.03 vs. 0.18 ± 0.03; Glu 10.46 ± 1.50 vs. 9.60 ± 1.19; Glu/tcr 1.23 ± 0.11 vs. 1.12 ± 0.11) (all p < 0.05). rsfMRI showed higher ReHo in the PM2.5 mice in the left superior colliculus, the left motor cortex, the hippocampus, the periaqueductal gray and the right mesencephalic reticular formation (all p < 0.01, AlphaSim corrected). Conclusions: This study revealed that PM2.5 exposure triggered visual dysfunction, and altered microstructure, metabolite and function in the retina and visual brain areas along the visual system.Linying GuoHe WangJi ZhouWeijun TangRong WangZebin XiaoLingjie WuJie WangLiping LiYuan LeiXinghuai SunZuohua TangElsevierarticleDiffusion tensor imagingPM2.5 exposureProton magnetic resonance spectroscopyResting state functional MRIVisual electrophysiologyEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112866- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diffusion tensor imaging PM2.5 exposure Proton magnetic resonance spectroscopy Resting state functional MRI Visual electrophysiology Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Diffusion tensor imaging PM2.5 exposure Proton magnetic resonance spectroscopy Resting state functional MRI Visual electrophysiology Environmental pollution TD172-193.5 Environmental sciences GE1-350 Linying Guo He Wang Ji Zhou Weijun Tang Rong Wang Zebin Xiao Lingjie Wu Jie Wang Liping Li Yuan Lei Xinghuai Sun Zuohua Tang Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice
description	Objectives: To investigate how PM2.5 exposure affects the microstructure, metabolites or functions of the visual system. Methods: C57BL/6J mice were randomly assigned to groups exposed to the filtered air (the control group) or the concentrated ambient PM2.5 (the PM2.5 group). Visual evoked potentials (VEP), electroretinograms (ERG), diffusion tensor imaging (DTI), proton magnetic resonance spectroscopy (1H-MRS) and resting-state functional MRI (rsfMRI) were performed. Parameters were obtained and compared between the two groups, including latencies and amplitudes of the P1 wave, N1 wave and P2 wave from VEP, latencies and amplitudes of the a wave and b wave from ERG, fractional anisotropy (FA), mean diffusion (MD), axial diffusivity (AD) and radial diffusivity (RD) from DTI, visual cortex (VC) metabolites from 1H-MRS, and regional homogeneity (ReHo) from rsfMRI. Results: Compared with the values of the control group, the PM2.5 group showed a prolonged N1 latency (43.11 ± 7.94 ms vs. 38.75 ± 4.60 ms) and lowered P1 amplitude (5.62 ± 4.38 μV vs. 8.56 ± 5.92 μV) on VEP (all p < 0.05). On ERG, the amplitude of the a wave was lowered (− 91.39 ± 56.29 μV vs. − 138.68 ± 89.05 μV), the amplitude of the b wave was lowered (194.38 ± 126.27 μV vs. 284.72 ± 170.99 μV), and the latency of the b wave was prolonged (37.78 ± 10.72 ms vs. 33.01 ± 4.34 ms) than the values of the control group (all p < 0.05). DTI indicated FA increase in the bilateral piriform cortex (Pir), FA decrease in the bilateral somatosensory cortex (S) and the bilateral striatum (Stri), AD decrease in the bilateral VC, the right S and the bilateral Pir, MD decrease in the bilateral Pir, and RD decrease in the bilateral Pir in the PM2.5 mice (all p < 0.05, Alphasim corrected). 1H-MRS showed Glutamate (Glu) increase and Phosphocholine (PCh) increase in the VC of the PM2.5 group than those of the control group (PCh 1.63 ± 0.25 vs. 1.50 ± 0.25; PCh/total creatine(tCr) 0.19 ± 0.03 vs. 0.18 ± 0.03; Glu 10.46 ± 1.50 vs. 9.60 ± 1.19; Glu/tcr 1.23 ± 0.11 vs. 1.12 ± 0.11) (all p < 0.05). rsfMRI showed higher ReHo in the PM2.5 mice in the left superior colliculus, the left motor cortex, the hippocampus, the periaqueductal gray and the right mesencephalic reticular formation (all p < 0.01, AlphaSim corrected). Conclusions: This study revealed that PM2.5 exposure triggered visual dysfunction, and altered microstructure, metabolite and function in the retina and visual brain areas along the visual system.
format	article
author	Linying Guo He Wang Ji Zhou Weijun Tang Rong Wang Zebin Xiao Lingjie Wu Jie Wang Liping Li Yuan Lei Xinghuai Sun Zuohua Tang
author_facet	Linying Guo He Wang Ji Zhou Weijun Tang Rong Wang Zebin Xiao Lingjie Wu Jie Wang Liping Li Yuan Lei Xinghuai Sun Zuohua Tang
author_sort	Linying Guo
title	Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice
title_short	Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice
title_full	Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice
title_fullStr	Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice
title_full_unstemmed	Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice
title_sort	magnetic resonance imaging investigations reveal that pm2.5 exposure triggers visual dysfunction in mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4c8e2814a6514118ac9ab6aeb88d0885
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Magnetic resonance imaging investigations reveal that PM2.5 exposure triggers visual dysfunction in mice

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