Expanding the genome-targeting scope and the site selectivity of high-precision base editors

Base editors can be limited by precision and the size of the target window. Here the authors test Cas9s that recognise alternative PAMs to obtain a series of high-precision editors.

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Detalles Bibliográficos
Autores principales:	Junjie Tan, Fei Zhang, Daniel Karcher, Ralph Bock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c8e2d4fc82f41ffb4aaddcc178d1e0f
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spelling	oai:doaj.org-article:4c8e2d4fc82f41ffb4aaddcc178d1e0f2021-12-02T15:37:17ZExpanding the genome-targeting scope and the site selectivity of high-precision base editors10.1038/s41467-020-14465-z2041-1723https://doaj.org/article/4c8e2d4fc82f41ffb4aaddcc178d1e0f2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14465-zhttps://doaj.org/toc/2041-1723Base editors can be limited by precision and the size of the target window. Here the authors test Cas9s that recognise alternative PAMs to obtain a series of high-precision editors.Junjie TanFei ZhangDaniel KarcherRalph BockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junjie Tan Fei Zhang Daniel Karcher Ralph Bock Expanding the genome-targeting scope and the site selectivity of high-precision base editors
description	Base editors can be limited by precision and the size of the target window. Here the authors test Cas9s that recognise alternative PAMs to obtain a series of high-precision editors.
format	article
author	Junjie Tan Fei Zhang Daniel Karcher Ralph Bock
author_facet	Junjie Tan Fei Zhang Daniel Karcher Ralph Bock
author_sort	Junjie Tan
title	Expanding the genome-targeting scope and the site selectivity of high-precision base editors
title_short	Expanding the genome-targeting scope and the site selectivity of high-precision base editors
title_full	Expanding the genome-targeting scope and the site selectivity of high-precision base editors
title_fullStr	Expanding the genome-targeting scope and the site selectivity of high-precision base editors
title_full_unstemmed	Expanding the genome-targeting scope and the site selectivity of high-precision base editors
title_sort	expanding the genome-targeting scope and the site selectivity of high-precision base editors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4c8e2d4fc82f41ffb4aaddcc178d1e0f
work_keys_str_mv	AT junjietan expandingthegenometargetingscopeandthesiteselectivityofhighprecisionbaseeditors AT feizhang expandingthegenometargetingscopeandthesiteselectivityofhighprecisionbaseeditors AT danielkarcher expandingthegenometargetingscopeandthesiteselectivityofhighprecisionbaseeditors AT ralphbock expandingthegenometargetingscopeandthesiteselectivityofhighprecisionbaseeditors
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Expanding the genome-targeting scope and the site selectivity of high-precision base editors

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