Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency

Several members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress. Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcrip...

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Autores principales:	Philip J. Murray, Eleonore Ocana, Hedda A. Meijer, Jacqueline Kim Dale
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	post transcriptional regulation translation mathematical model excitable oscillatory threshold Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/4c8e41eb6c494127b3aa0c9758730d73
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spelling	oai:doaj.org-article:4c8e41eb6c494127b3aa0c9758730d732021-11-25T16:51:55ZAuto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency10.3390/biom111115662218-273Xhttps://doaj.org/article/4c8e41eb6c494127b3aa0c9758730d732021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1566https://doaj.org/toc/2218-273XSeveral members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress. Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcription, splicing and transport, oscillations. Whilst previous models of autoinhibition of transcription have tended to treat processes such as translation as being unregulated (and hence linear), here we develop and explore a mathematical model that considers autoinhibition of transcription together with nonlinear regulation of translation. It is demonstrated that such a model can yield, in the absence of delays, nonlinear dynamical behaviours such as excitability, homeostasis, oscillations and intermittency. These results indicate that regulation of translation as well as transcription allows for a much richer range of behaviours than is possible with autoregulation of transcription alone. A number of experiments are suggested that would that allow for the signature of autoregulation of translation as well as transcription to be experimentally detected in a Notch signalling system.Philip J. MurrayEleonore OcanaHedda A. MeijerJacqueline Kim DaleMDPI AGarticlepost transcriptional regulationtranslationmathematical modelexcitableoscillatorythresholdMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1566, p 1566 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post transcriptional regulation translation mathematical model excitable oscillatory threshold Microbiology QR1-502
spellingShingle	post transcriptional regulation translation mathematical model excitable oscillatory threshold Microbiology QR1-502 Philip J. Murray Eleonore Ocana Hedda A. Meijer Jacqueline Kim Dale Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
description	Several members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress. Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcription, splicing and transport, oscillations. Whilst previous models of autoinhibition of transcription have tended to treat processes such as translation as being unregulated (and hence linear), here we develop and explore a mathematical model that considers autoinhibition of transcription together with nonlinear regulation of translation. It is demonstrated that such a model can yield, in the absence of delays, nonlinear dynamical behaviours such as excitability, homeostasis, oscillations and intermittency. These results indicate that regulation of translation as well as transcription allows for a much richer range of behaviours than is possible with autoregulation of transcription alone. A number of experiments are suggested that would that allow for the signature of autoregulation of translation as well as transcription to be experimentally detected in a Notch signalling system.
format	article
author	Philip J. Murray Eleonore Ocana Hedda A. Meijer Jacqueline Kim Dale
author_facet	Philip J. Murray Eleonore Ocana Hedda A. Meijer Jacqueline Kim Dale
author_sort	Philip J. Murray
title	Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
title_short	Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
title_full	Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
title_fullStr	Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
title_full_unstemmed	Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency
title_sort	auto-regulation of transcription and translation: oscillations, excitability and intermittency
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4c8e41eb6c494127b3aa0c9758730d73
work_keys_str_mv	AT philipjmurray autoregulationoftranscriptionandtranslationoscillationsexcitabilityandintermittency AT eleonoreocana autoregulationoftranscriptionandtranslationoscillationsexcitabilityandintermittency AT heddaameijer autoregulationoftranscriptionandtranslationoscillationsexcitabilityandintermittency AT jacquelinekimdale autoregulationoftranscriptionandtranslationoscillationsexcitabilityandintermittency
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Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency

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