Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers

Bladder cancer (BCa) and prostate cancer (PCa) are some of the most common cancers in the world. In both BCa and PCa, the diagnosis is often confirmed with an invasive technique that carries a risk to the patient. Consequently, a non-invasive diagnostic approach would be medically desirable and bene...

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Autores principales:	Heena Tyagi, Emma Daulton, Ayman S. Bannaga, Ramesh P. Arasaradnam, James A. Covington
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bladder cancer prostate cancer urinary biomarkers urinary VOCs machine olfaction GC-IMS Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/4c920679182643b1a72c89c5b329005d
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spelling	oai:doaj.org-article:4c920679182643b1a72c89c5b329005d2021-11-25T16:55:22ZUrinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers10.3390/bios111104372079-6374https://doaj.org/article/4c920679182643b1a72c89c5b329005d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/437https://doaj.org/toc/2079-6374Bladder cancer (BCa) and prostate cancer (PCa) are some of the most common cancers in the world. In both BCa and PCa, the diagnosis is often confirmed with an invasive technique that carries a risk to the patient. Consequently, a non-invasive diagnostic approach would be medically desirable and beneficial to the patient. The use of volatile organic compounds (VOCs) for disease diagnosis, including cancer, is a promising research area that could support the diagnosis process. In this study, we investigated the urinary VOC profiles in BCa, PCa patients and non-cancerous controls by using gas chromatography-ion mobility spectrometry (GC-IMS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) to analyse patient samples. GC-IMS separated BCa from PCa (area under the curve: AUC: 0.97 (0.93–1.00)), BCa vs. non-cancerous (AUC: 0.95 (0.90–0.99)) and PCa vs. non-cancerous (AUC: 0.89 (0.83–0.94)) whereas GC-TOF-MS differentiated BCa from PCa (AUC: 0.84 (0.73–0.93)), BCa vs. non-cancerous (AUC: 0.81 (0.70–0.90)) and PCa vs. non-cancerous (AUC: 0.94 (0.90–0.97)). According to our study, a total of 34 biomarkers were found using GC-TOF-MS data, of which 13 VOCs were associated with BCa, seven were associated with PCa, and 14 VOCs were found in the comparison of BCa and PCa.Heena TyagiEmma DaultonAyman S. BannagaRamesh P. ArasaradnamJames A. CovingtonMDPI AGarticlebladder cancerprostate cancerurinary biomarkersurinary VOCsmachine olfactionGC-IMSBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 437, p 437 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bladder cancer prostate cancer urinary biomarkers urinary VOCs machine olfaction GC-IMS Biotechnology TP248.13-248.65
spellingShingle	bladder cancer prostate cancer urinary biomarkers urinary VOCs machine olfaction GC-IMS Biotechnology TP248.13-248.65 Heena Tyagi Emma Daulton Ayman S. Bannaga Ramesh P. Arasaradnam James A. Covington Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers
description	Bladder cancer (BCa) and prostate cancer (PCa) are some of the most common cancers in the world. In both BCa and PCa, the diagnosis is often confirmed with an invasive technique that carries a risk to the patient. Consequently, a non-invasive diagnostic approach would be medically desirable and beneficial to the patient. The use of volatile organic compounds (VOCs) for disease diagnosis, including cancer, is a promising research area that could support the diagnosis process. In this study, we investigated the urinary VOC profiles in BCa, PCa patients and non-cancerous controls by using gas chromatography-ion mobility spectrometry (GC-IMS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) to analyse patient samples. GC-IMS separated BCa from PCa (area under the curve: AUC: 0.97 (0.93–1.00)), BCa vs. non-cancerous (AUC: 0.95 (0.90–0.99)) and PCa vs. non-cancerous (AUC: 0.89 (0.83–0.94)) whereas GC-TOF-MS differentiated BCa from PCa (AUC: 0.84 (0.73–0.93)), BCa vs. non-cancerous (AUC: 0.81 (0.70–0.90)) and PCa vs. non-cancerous (AUC: 0.94 (0.90–0.97)). According to our study, a total of 34 biomarkers were found using GC-TOF-MS data, of which 13 VOCs were associated with BCa, seven were associated with PCa, and 14 VOCs were found in the comparison of BCa and PCa.
format	article
author	Heena Tyagi Emma Daulton Ayman S. Bannaga Ramesh P. Arasaradnam James A. Covington
author_facet	Heena Tyagi Emma Daulton Ayman S. Bannaga Ramesh P. Arasaradnam James A. Covington
author_sort	Heena Tyagi
title	Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers
title_short	Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers
title_full	Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers
title_fullStr	Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers
title_full_unstemmed	Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers
title_sort	urinary volatiles and chemical characterisation for the non-invasive detection of prostate and bladder cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4c920679182643b1a72c89c5b329005d
work_keys_str_mv	AT heenatyagi urinaryvolatilesandchemicalcharacterisationforthenoninvasivedetectionofprostateandbladdercancers AT emmadaulton urinaryvolatilesandchemicalcharacterisationforthenoninvasivedetectionofprostateandbladdercancers AT aymansbannaga urinaryvolatilesandchemicalcharacterisationforthenoninvasivedetectionofprostateandbladdercancers AT rameshparasaradnam urinaryvolatilesandchemicalcharacterisationforthenoninvasivedetectionofprostateandbladdercancers AT jamesacovington urinaryvolatilesandchemicalcharacterisationforthenoninvasivedetectionofprostateandbladdercancers
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Urinary Volatiles and Chemical Characterisation for the Non-Invasive Detection of Prostate and Bladder Cancers

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