In vitro testing of silver-containing spacer in periprosthetic infection management

Abstract Deep infection is a serious complication in endoprosthetic surgery. In correlation to the patient local or systemic compromising factors conservative and surgical proceedings has to be evaluated. Systemic antibiotic therapy is the gold standard in infection management. Implanted silver-coat...

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Autores principales:	Renate Krassnig, Gloria Hohenberger, Angelika Schwarz, Walter Goessler, Gebhard Feierl, Renate Wildburger, Reinhard Windhager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c92c2220bbc4fdeb8158606b5d6f816
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spelling	oai:doaj.org-article:4c92c2220bbc4fdeb8158606b5d6f8162021-12-02T19:02:30ZIn vitro testing of silver-containing spacer in periprosthetic infection management10.1038/s41598-021-96811-92045-2322https://doaj.org/article/4c92c2220bbc4fdeb8158606b5d6f8162021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96811-9https://doaj.org/toc/2045-2322Abstract Deep infection is a serious complication in endoprosthetic surgery. In correlation to the patient local or systemic compromising factors conservative and surgical proceedings has to be evaluated. Systemic antibiotic therapy is the gold standard in infection management. Implanted silver-coated or silver-containing medical devices have been proven to their antimicrobial effectiveness since the 1990s by several investigators. The outcomes showed that long time implantation could cause damaging of the surrounding tissues, especially of adjacent nerves. The aim of our study was to evaluate the release of silver (I) ions from bone cement mixed with either nanosilver particles (AgNPs), different concentrations of silver sulfate (Ag2SO4) or from pure metallic silver strips. Therefore, we choose two methods: the first, called “static model”, was chosen to evaluate the maximal accumulative concentration of silver (I) ions, with the second, called “dynamic model”, we simulated a continuous reduction of the ions. In an additional test design, the different materials were evaluated for their antimicrobial activity using an agar gel diffusion assay. The outcome showed that neither the addition of 1% (w/w) nanosilver nor 0.1% silver sulfate (w/w) to polymethylmethacrylat bone cement has the ability to release silver (I) ions in a bactericidal/antifungal concentration. However, the results also showed that the addition of 0.5% (w/w) and 1% (w/w) silver sulfate (Ag2SO4) to bone cement is an effective amount of silver for use as a temporary spacer.Renate KrassnigGloria HohenbergerAngelika SchwarzWalter GoesslerGebhard FeierlRenate WildburgerReinhard WindhagerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renate Krassnig Gloria Hohenberger Angelika Schwarz Walter Goessler Gebhard Feierl Renate Wildburger Reinhard Windhager In vitro testing of silver-containing spacer in periprosthetic infection management
description	Abstract Deep infection is a serious complication in endoprosthetic surgery. In correlation to the patient local or systemic compromising factors conservative and surgical proceedings has to be evaluated. Systemic antibiotic therapy is the gold standard in infection management. Implanted silver-coated or silver-containing medical devices have been proven to their antimicrobial effectiveness since the 1990s by several investigators. The outcomes showed that long time implantation could cause damaging of the surrounding tissues, especially of adjacent nerves. The aim of our study was to evaluate the release of silver (I) ions from bone cement mixed with either nanosilver particles (AgNPs), different concentrations of silver sulfate (Ag2SO4) or from pure metallic silver strips. Therefore, we choose two methods: the first, called “static model”, was chosen to evaluate the maximal accumulative concentration of silver (I) ions, with the second, called “dynamic model”, we simulated a continuous reduction of the ions. In an additional test design, the different materials were evaluated for their antimicrobial activity using an agar gel diffusion assay. The outcome showed that neither the addition of 1% (w/w) nanosilver nor 0.1% silver sulfate (w/w) to polymethylmethacrylat bone cement has the ability to release silver (I) ions in a bactericidal/antifungal concentration. However, the results also showed that the addition of 0.5% (w/w) and 1% (w/w) silver sulfate (Ag2SO4) to bone cement is an effective amount of silver for use as a temporary spacer.
format	article
author	Renate Krassnig Gloria Hohenberger Angelika Schwarz Walter Goessler Gebhard Feierl Renate Wildburger Reinhard Windhager
author_facet	Renate Krassnig Gloria Hohenberger Angelika Schwarz Walter Goessler Gebhard Feierl Renate Wildburger Reinhard Windhager
author_sort	Renate Krassnig
title	In vitro testing of silver-containing spacer in periprosthetic infection management
title_short	In vitro testing of silver-containing spacer in periprosthetic infection management
title_full	In vitro testing of silver-containing spacer in periprosthetic infection management
title_fullStr	In vitro testing of silver-containing spacer in periprosthetic infection management
title_full_unstemmed	In vitro testing of silver-containing spacer in periprosthetic infection management
title_sort	in vitro testing of silver-containing spacer in periprosthetic infection management
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c92c2220bbc4fdeb8158606b5d6f816
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In vitro testing of silver-containing spacer in periprosthetic infection management

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