Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.

The severity of major depressive disorder (MDD), which is related to the depressive symptoms, is a predictor of clinical outcomes and may be used to determine the appropriate treatment. However, there is a lack of systematic research on the relationship between early depressive symptoms and MDD seve...

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Autores principales:	Tomoyuki Hirota, Yasuhiko Deguchi, Shinichi Iwasaki, Aya Sakaguchi, Akihiro Niki, Yoshiki Shirahama, Yoko Nakamichi, Koki Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c96aba365b74674b1f106c76d2b2c82
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spelling	oai:doaj.org-article:4c96aba365b74674b1f106c76d2b2c822021-12-02T20:04:57ZRelationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.1932-620310.1371/journal.pone.0255084https://doaj.org/article/4c96aba365b74674b1f106c76d2b2c822021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255084https://doaj.org/toc/1932-6203The severity of major depressive disorder (MDD), which is related to the depressive symptoms, is a predictor of clinical outcomes and may be used to determine the appropriate treatment. However, there is a lack of systematic research on the relationship between early depressive symptoms and MDD severity. This study aimed to clarify the association between initial depressive symptoms and MDD severity in working patients. We assessed 118 patients aged over 20 years who visited the Neuropsychiatry Department of the Osaka City University Hospital following their first episode of MDD. Logistic regression analyses were performed to estimate the odds ratios (OR) with 95% confidence intervals (CI) for the associations between age, gender, marital status, working hours, and initial self-perceived depressive symptoms and MDD severity. Age and working hours were analyzed as continuous variables, and gender (man, woman), marital status (married, single) and severity (mild to moderate MDD, severe to very severe MDD) were analyzed as categorical variables. The most common initial self-perceived symptom was "depressed mood," followed by "fatigue or loss of energy nearly every day." The univariate analysis found no association between age, gender, marital status, or working hours and MDD severity. Initial self-perceived non-somatic symptoms were associated with increased odds of having severe MDD (odds ratio = 3.32, 95% confidence interval 1.46-7.58), and this association persisted in the adjusted model (odds ratio = 3.35, 95% confidence interval 1.47-7.60). Initial self-perceived non-somatic depressive symptoms are significantly associated with MDD severity at its first onset. Workplace support may lead to the early detection and treatment of working patients with non-somatic symptoms.Tomoyuki HirotaYasuhiko DeguchiShinichi IwasakiAya SakaguchiAkihiro NikiYoshiki ShirahamaYoko NakamichiKoki InouePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255084 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoyuki Hirota Yasuhiko Deguchi Shinichi Iwasaki Aya Sakaguchi Akihiro Niki Yoshiki Shirahama Yoko Nakamichi Koki Inoue Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
description	The severity of major depressive disorder (MDD), which is related to the depressive symptoms, is a predictor of clinical outcomes and may be used to determine the appropriate treatment. However, there is a lack of systematic research on the relationship between early depressive symptoms and MDD severity. This study aimed to clarify the association between initial depressive symptoms and MDD severity in working patients. We assessed 118 patients aged over 20 years who visited the Neuropsychiatry Department of the Osaka City University Hospital following their first episode of MDD. Logistic regression analyses were performed to estimate the odds ratios (OR) with 95% confidence intervals (CI) for the associations between age, gender, marital status, working hours, and initial self-perceived depressive symptoms and MDD severity. Age and working hours were analyzed as continuous variables, and gender (man, woman), marital status (married, single) and severity (mild to moderate MDD, severe to very severe MDD) were analyzed as categorical variables. The most common initial self-perceived symptom was "depressed mood," followed by "fatigue or loss of energy nearly every day." The univariate analysis found no association between age, gender, marital status, or working hours and MDD severity. Initial self-perceived non-somatic symptoms were associated with increased odds of having severe MDD (odds ratio = 3.32, 95% confidence interval 1.46-7.58), and this association persisted in the adjusted model (odds ratio = 3.35, 95% confidence interval 1.47-7.60). Initial self-perceived non-somatic depressive symptoms are significantly associated with MDD severity at its first onset. Workplace support may lead to the early detection and treatment of working patients with non-somatic symptoms.
format	article
author	Tomoyuki Hirota Yasuhiko Deguchi Shinichi Iwasaki Aya Sakaguchi Akihiro Niki Yoshiki Shirahama Yoko Nakamichi Koki Inoue
author_facet	Tomoyuki Hirota Yasuhiko Deguchi Shinichi Iwasaki Aya Sakaguchi Akihiro Niki Yoshiki Shirahama Yoko Nakamichi Koki Inoue
author_sort	Tomoyuki Hirota
title	Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
title_short	Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
title_full	Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
title_fullStr	Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
title_full_unstemmed	Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
title_sort	relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4c96aba365b74674b1f106c76d2b2c82
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Relationship between initial self-perceived depressive symptoms and disease severity in working patients with first-onset major depressive disorder.

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