Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour-suppression mechanism.

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Autores principales: Shingo Miyawaki, Yoshimi Kawamura, Yuki Oiwa, Atsushi Shimizu, Tsuyoshi Hachiya, Hidemasa Bono, Ikuko Koya, Yohei Okada, Tokuhiro Kimura, Yoshihiro Tsuchiya, Sadafumi Suzuki, Nobuyuki Onishi, Naoko Kuzumaki, Yumi Matsuzaki, Minoru Narita, Eiji Ikeda, Kazuo Okanoya, Ken-ichiro Seino, Hideyuki Saya, Hideyuki Okano, Kyoko Miura
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4c96ca7ac9674011acb4f973f6e4f4db
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spelling oai:doaj.org-article:4c96ca7ac9674011acb4f973f6e4f4db2021-12-02T14:40:12ZTumour resistance in induced pluripotent stem cells derived from naked mole-rats10.1038/ncomms114712041-1723https://doaj.org/article/4c96ca7ac9674011acb4f973f6e4f4db2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11471https://doaj.org/toc/2041-1723The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour-suppression mechanism.Shingo MiyawakiYoshimi KawamuraYuki OiwaAtsushi ShimizuTsuyoshi HachiyaHidemasa BonoIkuko KoyaYohei OkadaTokuhiro KimuraYoshihiro TsuchiyaSadafumi SuzukiNobuyuki OnishiNaoko KuzumakiYumi MatsuzakiMinoru NaritaEiji IkedaKazuo OkanoyaKen-ichiro SeinoHideyuki SayaHideyuki OkanoKyoko MiuraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shingo Miyawaki
Yoshimi Kawamura
Yuki Oiwa
Atsushi Shimizu
Tsuyoshi Hachiya
Hidemasa Bono
Ikuko Koya
Yohei Okada
Tokuhiro Kimura
Yoshihiro Tsuchiya
Sadafumi Suzuki
Nobuyuki Onishi
Naoko Kuzumaki
Yumi Matsuzaki
Minoru Narita
Eiji Ikeda
Kazuo Okanoya
Ken-ichiro Seino
Hideyuki Saya
Hideyuki Okano
Kyoko Miura
Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
description The naked mole-rat exhibits an exceptional resistance to cancer. Here, the authors show that induced pluripotent stem cells derived from the naked mole-rat lack teratoma-forming tumorigenicity due to a naked mole-rat-specific ARF-dependent tumour-suppression mechanism.
format article
author Shingo Miyawaki
Yoshimi Kawamura
Yuki Oiwa
Atsushi Shimizu
Tsuyoshi Hachiya
Hidemasa Bono
Ikuko Koya
Yohei Okada
Tokuhiro Kimura
Yoshihiro Tsuchiya
Sadafumi Suzuki
Nobuyuki Onishi
Naoko Kuzumaki
Yumi Matsuzaki
Minoru Narita
Eiji Ikeda
Kazuo Okanoya
Ken-ichiro Seino
Hideyuki Saya
Hideyuki Okano
Kyoko Miura
author_facet Shingo Miyawaki
Yoshimi Kawamura
Yuki Oiwa
Atsushi Shimizu
Tsuyoshi Hachiya
Hidemasa Bono
Ikuko Koya
Yohei Okada
Tokuhiro Kimura
Yoshihiro Tsuchiya
Sadafumi Suzuki
Nobuyuki Onishi
Naoko Kuzumaki
Yumi Matsuzaki
Minoru Narita
Eiji Ikeda
Kazuo Okanoya
Ken-ichiro Seino
Hideyuki Saya
Hideyuki Okano
Kyoko Miura
author_sort Shingo Miyawaki
title Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
title_short Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
title_full Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
title_fullStr Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
title_full_unstemmed Tumour resistance in induced pluripotent stem cells derived from naked mole-rats
title_sort tumour resistance in induced pluripotent stem cells derived from naked mole-rats
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/4c96ca7ac9674011acb4f973f6e4f4db
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