CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome
Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4...
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Nature Portfolio
2019
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oai:doaj.org-article:4c98395f104445a7a39848447428e6cc2021-12-02T15:35:16ZCD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome10.1038/s41467-019-13593-52041-1723https://doaj.org/article/4c98395f104445a7a39848447428e6cc2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13593-5https://doaj.org/toc/2041-1723Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4 patients.Catharina C. GrossCéline MeyerUrvashi BhatiaLidia YshiiIlka KleffnerJan BauerAnna R. TröscherAndreas Schulte-MecklenbeckSebastian HerichTilman Schneider-HohendorfHenrike PlateTanja KuhlmannMarkus SchwaningerWolfgang BrückMarc PawlitzkiDavid-Axel LaplaudDelphine LoussouarnJohn ParrattMichael BarnettMichael E. BucklandTodd A. HardyStephen W. ReddelMarius RingelsteinJan DörrBrigitte WildemannMarkus KraemerHans LassmannRomana HöftbergerEduardo BeltránKlaus DornmairNicholas SchwabLuisa KlotzSven G. MeuthGuillaume Martin-BlondelHeinz WiendlRoland LiblauNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Catharina C. Gross Céline Meyer Urvashi Bhatia Lidia Yshii Ilka Kleffner Jan Bauer Anna R. Tröscher Andreas Schulte-Mecklenbeck Sebastian Herich Tilman Schneider-Hohendorf Henrike Plate Tanja Kuhlmann Markus Schwaninger Wolfgang Brück Marc Pawlitzki David-Axel Laplaud Delphine Loussouarn John Parratt Michael Barnett Michael E. Buckland Todd A. Hardy Stephen W. Reddel Marius Ringelstein Jan Dörr Brigitte Wildemann Markus Kraemer Hans Lassmann Romana Höftberger Eduardo Beltrán Klaus Dornmair Nicholas Schwab Luisa Klotz Sven G. Meuth Guillaume Martin-Blondel Heinz Wiendl Roland Liblau CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome |
| description |
Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4 patients. |
| format |
article |
| author |
Catharina C. Gross Céline Meyer Urvashi Bhatia Lidia Yshii Ilka Kleffner Jan Bauer Anna R. Tröscher Andreas Schulte-Mecklenbeck Sebastian Herich Tilman Schneider-Hohendorf Henrike Plate Tanja Kuhlmann Markus Schwaninger Wolfgang Brück Marc Pawlitzki David-Axel Laplaud Delphine Loussouarn John Parratt Michael Barnett Michael E. Buckland Todd A. Hardy Stephen W. Reddel Marius Ringelstein Jan Dörr Brigitte Wildemann Markus Kraemer Hans Lassmann Romana Höftberger Eduardo Beltrán Klaus Dornmair Nicholas Schwab Luisa Klotz Sven G. Meuth Guillaume Martin-Blondel Heinz Wiendl Roland Liblau |
| author_facet |
Catharina C. Gross Céline Meyer Urvashi Bhatia Lidia Yshii Ilka Kleffner Jan Bauer Anna R. Tröscher Andreas Schulte-Mecklenbeck Sebastian Herich Tilman Schneider-Hohendorf Henrike Plate Tanja Kuhlmann Markus Schwaninger Wolfgang Brück Marc Pawlitzki David-Axel Laplaud Delphine Loussouarn John Parratt Michael Barnett Michael E. Buckland Todd A. Hardy Stephen W. Reddel Marius Ringelstein Jan Dörr Brigitte Wildemann Markus Kraemer Hans Lassmann Romana Höftberger Eduardo Beltrán Klaus Dornmair Nicholas Schwab Luisa Klotz Sven G. Meuth Guillaume Martin-Blondel Heinz Wiendl Roland Liblau |
| author_sort |
Catharina C. Gross |
| title |
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome |
| title_short |
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome |
| title_full |
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome |
| title_fullStr |
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome |
| title_full_unstemmed |
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome |
| title_sort |
cd8+ t cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in susac syndrome |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4c98395f104445a7a39848447428e6cc |
| work_keys_str_mv |
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