Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.

Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However...

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Autores principales:	Niall W Duncan, Christine Wiebking, Brice Tiret, Malgorzata Marjańska, Dave J Hayes, Oliver Lyttleton, Julien Doyon, Georg Northoff
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c98499bc27a4266ac4c5593af2dd211
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spelling	oai:doaj.org-article:4c98499bc27a4266ac4c5593af2dd2112021-11-18T07:50:45ZGlutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.1932-620310.1371/journal.pone.0060312https://doaj.org/article/4c98499bc27a4266ac4c5593af2dd2112013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23573246/?tool=EBIhttps://doaj.org/toc/1932-6203Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However, to date no experiments that link these factors in humans in vivo have been carried out. To investigate the role of glutamate in individual differences in communication between the cortex--specifically the medial prefrontal cortex (mPFC)--and subcortical regions in humans, a combination of resting-state fMRI, DTI and MRS was performed. The subcortical target regions were the nucleus accumbens (NAc), dorsomedial thalamus (DMT), and periaqueductal grey (PAG). It was found that functional connectivity between the mPFC and each of the NAc and DMT was positively correlated with mPFC glutamate concentrations, whilst functional connectivity between the mPFC and PAG was negatively correlated with glutamate concentration. The correlations involving mPFC glutamate and FC between the mPFC and each of the DMT and PAG were mirrored by correlations with structural connectivity, providing evidence that the glutamatergic relationship may, in part, be due to direct connectivity. These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia.Niall W DuncanChristine WiebkingBrice TiretMalgorzata MarjańskaDave J HayesOliver LyttletonJulien DoyonGeorg NorthoffPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60312 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Niall W Duncan Christine Wiebking Brice Tiret Malgorzata Marjańska Dave J Hayes Oliver Lyttleton Julien Doyon Georg Northoff Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
description	Communication between cortical and subcortical regions is integral to a wide range of psychological processes and has been implicated in a number of psychiatric conditions. Studies in animals have provided insight into the biochemical and connectivity processes underlying such communication. However, to date no experiments that link these factors in humans in vivo have been carried out. To investigate the role of glutamate in individual differences in communication between the cortex--specifically the medial prefrontal cortex (mPFC)--and subcortical regions in humans, a combination of resting-state fMRI, DTI and MRS was performed. The subcortical target regions were the nucleus accumbens (NAc), dorsomedial thalamus (DMT), and periaqueductal grey (PAG). It was found that functional connectivity between the mPFC and each of the NAc and DMT was positively correlated with mPFC glutamate concentrations, whilst functional connectivity between the mPFC and PAG was negatively correlated with glutamate concentration. The correlations involving mPFC glutamate and FC between the mPFC and each of the DMT and PAG were mirrored by correlations with structural connectivity, providing evidence that the glutamatergic relationship may, in part, be due to direct connectivity. These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia.
format	article
author	Niall W Duncan Christine Wiebking Brice Tiret Malgorzata Marjańska Dave J Hayes Oliver Lyttleton Julien Doyon Georg Northoff
author_facet	Niall W Duncan Christine Wiebking Brice Tiret Malgorzata Marjańska Dave J Hayes Oliver Lyttleton Julien Doyon Georg Northoff
author_sort	Niall W Duncan
title	Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
title_short	Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
title_full	Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
title_fullStr	Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
title_full_unstemmed	Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
title_sort	glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4c98499bc27a4266ac4c5593af2dd211
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Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans.

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