Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice

Abstract Hand choices—deciding which hand to use to reach for targets—represent continuous, daily, unconscious decisions. The posterior parietal cortex (PPC) contralateral to the selected hand is activated during a hand-choice task, and disruption of left PPC activity with a single-pulse transcrania...

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Autores principales:	Kento Hirayama, Takayuki Koga, Toru Takahashi, Rieko Osu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c99737f29d3490b906633989601577d
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spelling	oai:doaj.org-article:4c99737f29d3490b906633989601577d2021-12-02T11:45:55ZTranscranial direct current stimulation of the posterior parietal cortex biases human hand choice10.1038/s41598-020-80611-82045-2322https://doaj.org/article/4c99737f29d3490b906633989601577d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80611-8https://doaj.org/toc/2045-2322Abstract Hand choices—deciding which hand to use to reach for targets—represent continuous, daily, unconscious decisions. The posterior parietal cortex (PPC) contralateral to the selected hand is activated during a hand-choice task, and disruption of left PPC activity with a single-pulse transcranial magnetic stimulation prior to the execution of the motion suppresses the choice to use the right hand but not vice versa. These findings imply the involvement of either bilateral or left PPC in hand choice. To determine whether the effects of PPC’s activity are essential and/or symmetrical in hand choice, we increased or decreased PPC excitability in 16 healthy participants using transcranial direct current stimulation (tDCS; 10 min, 2 mA, 5 × 7 cm) and examined its online and residual effects on hand-choice probability and reaction time. After the right PPC was stimulated with an anode and the left PPC with a cathode, the probability of left-hand choice significantly increased and reaction time significantly decreased. However, no significant changes were observed with the stimulation of the right PPC with a cathode and the left PPC with an anode. These findings, thus, reveal the asymmetry of PPC-mediated regulation in hand choice.Kento HirayamaTakayuki KogaToru TakahashiRieko OsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kento Hirayama Takayuki Koga Toru Takahashi Rieko Osu Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
description	Abstract Hand choices—deciding which hand to use to reach for targets—represent continuous, daily, unconscious decisions. The posterior parietal cortex (PPC) contralateral to the selected hand is activated during a hand-choice task, and disruption of left PPC activity with a single-pulse transcranial magnetic stimulation prior to the execution of the motion suppresses the choice to use the right hand but not vice versa. These findings imply the involvement of either bilateral or left PPC in hand choice. To determine whether the effects of PPC’s activity are essential and/or symmetrical in hand choice, we increased or decreased PPC excitability in 16 healthy participants using transcranial direct current stimulation (tDCS; 10 min, 2 mA, 5 × 7 cm) and examined its online and residual effects on hand-choice probability and reaction time. After the right PPC was stimulated with an anode and the left PPC with a cathode, the probability of left-hand choice significantly increased and reaction time significantly decreased. However, no significant changes were observed with the stimulation of the right PPC with a cathode and the left PPC with an anode. These findings, thus, reveal the asymmetry of PPC-mediated regulation in hand choice.
format	article
author	Kento Hirayama Takayuki Koga Toru Takahashi Rieko Osu
author_facet	Kento Hirayama Takayuki Koga Toru Takahashi Rieko Osu
author_sort	Kento Hirayama
title	Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
title_short	Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
title_full	Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
title_fullStr	Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
title_full_unstemmed	Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
title_sort	transcranial direct current stimulation of the posterior parietal cortex biases human hand choice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c99737f29d3490b906633989601577d
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Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice

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