Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside

Cyanidin-3-<i>O</i>-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and α-glucosidase inhibition effects. Nevertheless, the physiological relevance of such properties remains uncertain considering its sig...

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Autores principales:	Didier Fraisse, Alexis Bred, Catherine Felgines, François Senejoux
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cyanidin-3-<i>O</i>-glucoside kuromanin anthocyanin antioxidant glycation glucosidase Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4c9c026b82cc449a9dfb7221a92a47b1
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spelling	oai:doaj.org-article:4c9c026b82cc449a9dfb7221a92a47b12021-11-25T16:25:46ZImpact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside10.3390/antiox101116702076-3921https://doaj.org/article/4c9c026b82cc449a9dfb7221a92a47b12021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1670https://doaj.org/toc/2076-3921Cyanidin-3-<i>O</i>-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and α-glucosidase inhibition effects. Nevertheless, the physiological relevance of such properties remains uncertain considering its significant instability in gastrointestinal conditions. A simulated digestion procedure was thus instigated to assess the influence of gastric and intestinal media on its chemical integrity and biological activities. HPLC analyses of digested C3G samples confirmed the striking impact of intestinal conditions, as attested by a decomposition ratio of 70%. In contrast, with recovery rates of around 90%, antiglycation, as well as DPPH and ABTS scavenging assays, uniformly revealed a noteworthy persistence of its antiglycoxidant capacities. Remarkably, a prominent increase of its α-glucosidase inhibition activity was even observed after the intestinal phase, suggesting that classical in vitro evaluations might underestimate C3G antidiabetic potential. Consequently, the present data provide novel and specific insights on C3G’s digestive fate, suggesting that the gastrointestinal tract does not profoundly affect its positive action on oxidative and carbonyl stresses. More specifically, it also tends to support its regulating effects on postprandial hyperglycemia and its potential usefulness for diabetes management.Didier FraisseAlexis BredCatherine FelginesFrançois SenejouxMDPI AGarticlecyanidin-3-<i>O</i>-glucosidekuromaninanthocyaninantioxidantglycationglucosidaseTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1670, p 1670 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cyanidin-3-<i>O</i>-glucoside kuromanin anthocyanin antioxidant glycation glucosidase Therapeutics. Pharmacology RM1-950
spellingShingle	cyanidin-3-<i>O</i>-glucoside kuromanin anthocyanin antioxidant glycation glucosidase Therapeutics. Pharmacology RM1-950 Didier Fraisse Alexis Bred Catherine Felgines François Senejoux Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside
description	Cyanidin-3-<i>O</i>-glucoside (C3G) is a widespread anthocyanin derivative, which has been reported in vitro to exert potent antioxidant, antiglycation and α-glucosidase inhibition effects. Nevertheless, the physiological relevance of such properties remains uncertain considering its significant instability in gastrointestinal conditions. A simulated digestion procedure was thus instigated to assess the influence of gastric and intestinal media on its chemical integrity and biological activities. HPLC analyses of digested C3G samples confirmed the striking impact of intestinal conditions, as attested by a decomposition ratio of 70%. In contrast, with recovery rates of around 90%, antiglycation, as well as DPPH and ABTS scavenging assays, uniformly revealed a noteworthy persistence of its antiglycoxidant capacities. Remarkably, a prominent increase of its α-glucosidase inhibition activity was even observed after the intestinal phase, suggesting that classical in vitro evaluations might underestimate C3G antidiabetic potential. Consequently, the present data provide novel and specific insights on C3G’s digestive fate, suggesting that the gastrointestinal tract does not profoundly affect its positive action on oxidative and carbonyl stresses. More specifically, it also tends to support its regulating effects on postprandial hyperglycemia and its potential usefulness for diabetes management.
format	article
author	Didier Fraisse Alexis Bred Catherine Felgines François Senejoux
author_facet	Didier Fraisse Alexis Bred Catherine Felgines François Senejoux
author_sort	Didier Fraisse
title	Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside
title_short	Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside
title_full	Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside
title_fullStr	Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside
title_full_unstemmed	Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside
title_sort	impact of simulated gastrointestinal conditions on antiglycoxidant and α-glucosidase inhibition capacities of cyanidin-3-<i>o</i>-glucoside
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4c9c026b82cc449a9dfb7221a92a47b1
work_keys_str_mv	AT didierfraisse impactofsimulatedgastrointestinalconditionsonantiglycoxidantandaglucosidaseinhibitioncapacitiesofcyanidin3ioiglucoside AT alexisbred impactofsimulatedgastrointestinalconditionsonantiglycoxidantandaglucosidaseinhibitioncapacitiesofcyanidin3ioiglucoside AT catherinefelgines impactofsimulatedgastrointestinalconditionsonantiglycoxidantandaglucosidaseinhibitioncapacitiesofcyanidin3ioiglucoside AT francoissenejoux impactofsimulatedgastrointestinalconditionsonantiglycoxidantandaglucosidaseinhibitioncapacitiesofcyanidin3ioiglucoside
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Impact of Simulated Gastrointestinal Conditions on Antiglycoxidant and α-Glucosidase Inhibition Capacities of Cyanidin-3-<i>O</i>-Glucoside

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