SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury

Abstract In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the...

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Autores principales:	Jin-Ze Tian, Sheng Xing, Jing-Yi Feng, Shu-Hua Yang, Yan-Fu Ding, Xue-Ting Huang, Jin-Shu Yang, Wei-Jun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c9c21167fb5432ab48970a6f6617e93
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spelling	oai:doaj.org-article:4c9c21167fb5432ab48970a6f6617e932021-12-02T17:40:45ZSETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury10.1038/s41598-021-92075-52045-2322https://doaj.org/article/4c9c21167fb5432ab48970a6f6617e932021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92075-5https://doaj.org/toc/2045-2322Abstract In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the adult mouse pancreas. Genetic lineage tracing shows that during pancreatic development, descendants of SETD4+ cells make up over 70% of pancreatic cells and then contribute to each pancreatic lineage during pancreatic homeostasis. SETD4+ cells generate newborn acinar cells in response to cerulein-induced pancreatitis in acinar compartments. Ablation of SETD4+ cells compromises regeneration of acinar cells, in contrast to controls. Our findings provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population. Potential applications may act to preserve pancreatic function in case of pancreatic disease and/or damage.Jin-Ze TianSheng XingJing-Yi FengShu-Hua YangYan-Fu DingXue-Ting HuangJin-Shu YangWei-Jun YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin-Ze Tian Sheng Xing Jing-Yi Feng Shu-Hua Yang Yan-Fu Ding Xue-Ting Huang Jin-Shu Yang Wei-Jun Yang SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
description	Abstract In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the adult mouse pancreas. Genetic lineage tracing shows that during pancreatic development, descendants of SETD4+ cells make up over 70% of pancreatic cells and then contribute to each pancreatic lineage during pancreatic homeostasis. SETD4+ cells generate newborn acinar cells in response to cerulein-induced pancreatitis in acinar compartments. Ablation of SETD4+ cells compromises regeneration of acinar cells, in contrast to controls. Our findings provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population. Potential applications may act to preserve pancreatic function in case of pancreatic disease and/or damage.
format	article
author	Jin-Ze Tian Sheng Xing Jing-Yi Feng Shu-Hua Yang Yan-Fu Ding Xue-Ting Huang Jin-Shu Yang Wei-Jun Yang
author_facet	Jin-Ze Tian Sheng Xing Jing-Yi Feng Shu-Hua Yang Yan-Fu Ding Xue-Ting Huang Jin-Shu Yang Wei-Jun Yang
author_sort	Jin-Ze Tian
title	SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
title_short	SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
title_full	SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
title_fullStr	SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
title_full_unstemmed	SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
title_sort	setd4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c9c21167fb5432ab48970a6f6617e93
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SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury

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