The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus

The study of diabetes mellitus (DM), its complications and related pathologies has been continuously performed for many years; however, despite the substantial work and outstanding achievements in studying the mechanisms of DM development and the success of new medicinal products for controlling gly...

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Autores principales:	Alexander Alexandrovich Chernikov, Anastasia Sergeevna Severina, Minara Shamhalovna Shamhalova, Marina Vladimirovna Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	diabetes mellitus metabolic memory oxidative stress epigenetics advanced glycation end products Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/4c9c32339c164846a0ce8509f015c5c7
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spelling	oai:doaj.org-article:4c9c32339c164846a0ce8509f015c5c72021-11-14T09:00:21ZThe role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus2072-03512072-037810.14341/7674https://doaj.org/article/4c9c32339c164846a0ce8509f015c5c72017-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8684https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The study of diabetes mellitus (DM), its complications and related pathologies has been continuously performed for many years; however, despite the substantial work and outstanding achievements in studying the mechanisms of DM development and the success of new medicinal products for controlling glycaemia, the problems associated with the late complications of DM continue to increase. The importance of glycaemic control in the early stages of DM for the development of complications is seen only after a sufficiently long period of observation. Such a delayed effect of primary good or unsatisfactory metabolic control, which shapes the patient’s clinical fate to a greater extent, is termed ‘metabolic memory’. The disorders developed under the influence of hyperglycaemia persist for long periods after the normalisation of carbohydrate metabolism; moreover, the effect of previous hyperglycaemia extends over the next 20 and even 30 years. Current research is focused on the possible mechanisms of metabolic memory development, including oxidative stress, advanced glycation end products and epigenetic mechanisms. This research will provide insight into potential markers for the early development and progression of vascular complications and new therapeutic possibilities for the future. However, determining the probable ‘point of no return’ is more important, which implies that a point exists; after this point is crossed, the progression of vascular complications associated with DM cannot be prevented or reversed. The results of numerous experimental studies demonstrate that the prerequisite components of metabolic memory can be used as potential markers of the progression of DM complications, and may be potential therapeutic targets.Alexander Alexandrovich ChernikovAnastasia Sergeevna SeverinaMinara Shamhalovna ShamhalovaMarina Vladimirovna ShestakovaEndocrinology Research Centrearticlediabetes mellitusmetabolic memoryoxidative stressepigeneticsadvanced glycation end productsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 2, Pp 126-134 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus metabolic memory oxidative stress epigenetics advanced glycation end products Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus metabolic memory oxidative stress epigenetics advanced glycation end products Nutritional diseases. Deficiency diseases RC620-627 Alexander Alexandrovich Chernikov Anastasia Sergeevna Severina Minara Shamhalovna Shamhalova Marina Vladimirovna Shestakova The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
description	The study of diabetes mellitus (DM), its complications and related pathologies has been continuously performed for many years; however, despite the substantial work and outstanding achievements in studying the mechanisms of DM development and the success of new medicinal products for controlling glycaemia, the problems associated with the late complications of DM continue to increase. The importance of glycaemic control in the early stages of DM for the development of complications is seen only after a sufficiently long period of observation. Such a delayed effect of primary good or unsatisfactory metabolic control, which shapes the patient’s clinical fate to a greater extent, is termed ‘metabolic memory’. The disorders developed under the influence of hyperglycaemia persist for long periods after the normalisation of carbohydrate metabolism; moreover, the effect of previous hyperglycaemia extends over the next 20 and even 30 years. Current research is focused on the possible mechanisms of metabolic memory development, including oxidative stress, advanced glycation end products and epigenetic mechanisms. This research will provide insight into potential markers for the early development and progression of vascular complications and new therapeutic possibilities for the future. However, determining the probable ‘point of no return’ is more important, which implies that a point exists; after this point is crossed, the progression of vascular complications associated with DM cannot be prevented or reversed. The results of numerous experimental studies demonstrate that the prerequisite components of metabolic memory can be used as potential markers of the progression of DM complications, and may be potential therapeutic targets.
format	article
author	Alexander Alexandrovich Chernikov Anastasia Sergeevna Severina Minara Shamhalovna Shamhalova Marina Vladimirovna Shestakova
author_facet	Alexander Alexandrovich Chernikov Anastasia Sergeevna Severina Minara Shamhalovna Shamhalova Marina Vladimirovna Shestakova
author_sort	Alexander Alexandrovich Chernikov
title	The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
title_short	The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
title_full	The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
title_fullStr	The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
title_full_unstemmed	The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
title_sort	role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/4c9c32339c164846a0ce8509f015c5c7
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The role of «metabolic memory» mechanisms in the development and progression of vascular complications of diabetes mellitus

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