Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress

Abstract Resilience has been conceptualized in part as a dynamic process that includes the ability to adapt to stressful conditions. As such it encompasses the extent to which neural plasticity may be promoted. The current study examined metaplasticity by referring to the “plasticity of synaptic pla...

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Autores principales:	Omer Horovitz, Alon Richter-Levin, Lin Xu, Liang Jing, Gal Richter-Levin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4c9dd3711fa643ed97219f6b504ed91c
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spelling	oai:doaj.org-article:4c9dd3711fa643ed97219f6b504ed91c2021-12-02T16:06:04ZPeriaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress10.1038/s41598-017-00562-52045-2322https://doaj.org/article/4c9dd3711fa643ed97219f6b504ed91c2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00562-5https://doaj.org/toc/2045-2322Abstract Resilience has been conceptualized in part as a dynamic process that includes the ability to adapt to stressful conditions. As such it encompasses the extent to which neural plasticity may be promoted. The current study examined metaplasticity by referring to the “plasticity of synaptic plasticity” in a neural circuit composed of the basolateral amygdala (BLA) and the nucleus accumbens (NAcc), using behavioural stress controllability with or without preceding stimulation of the dorsal periaqueductal gray (i.e. dPAG priming). A tendency for increased plasticity in the controllable versus the uncontrollable group was found in both the BLA and NAcc. dPAG priming suppressed NAcc LTP in all groups, but it suppressed BLA LTP only in the uncontrollable group, demonstrating dissociation between either controllable and uncontrollable groups or the NAcc and BLA. Thus, metaplasticity in the dPAG-BLA-NAcc circuit regulated differentially by controllable or uncontrollable stress may underlie stress coping, and thus contribute to stress-related psychopathologies.Omer HorovitzAlon Richter-LevinLin XuLiang JingGal Richter-LevinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Omer Horovitz Alon Richter-Levin Lin Xu Liang Jing Gal Richter-Levin Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress
description	Abstract Resilience has been conceptualized in part as a dynamic process that includes the ability to adapt to stressful conditions. As such it encompasses the extent to which neural plasticity may be promoted. The current study examined metaplasticity by referring to the “plasticity of synaptic plasticity” in a neural circuit composed of the basolateral amygdala (BLA) and the nucleus accumbens (NAcc), using behavioural stress controllability with or without preceding stimulation of the dorsal periaqueductal gray (i.e. dPAG priming). A tendency for increased plasticity in the controllable versus the uncontrollable group was found in both the BLA and NAcc. dPAG priming suppressed NAcc LTP in all groups, but it suppressed BLA LTP only in the uncontrollable group, demonstrating dissociation between either controllable and uncontrollable groups or the NAcc and BLA. Thus, metaplasticity in the dPAG-BLA-NAcc circuit regulated differentially by controllable or uncontrollable stress may underlie stress coping, and thus contribute to stress-related psychopathologies.
format	article
author	Omer Horovitz Alon Richter-Levin Lin Xu Liang Jing Gal Richter-Levin
author_facet	Omer Horovitz Alon Richter-Levin Lin Xu Liang Jing Gal Richter-Levin
author_sort	Omer Horovitz
title	Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress
title_short	Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress
title_full	Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress
title_fullStr	Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress
title_full_unstemmed	Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress
title_sort	periaqueductal grey differential modulation of nucleus accumbens and basolateral amygdala plasticity under controllable and uncontrollable stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4c9dd3711fa643ed97219f6b504ed91c
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Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral Amygdala plasticity under controllable and uncontrollable stress

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