Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells

Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary. Using insl3 knockout zebrafish, the authors found that Insl3 regulates spermatogonia differentiation and ap...

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Autores principales:	Diego Crespo, Luiz H. C. Assis, Yu Ting Zhang, Diego Safian, Tomasz Furmanek, Kai Ove Skaftnesmo, Birgitta Norberg, Wei Ge, Yung-Ching Choi, Marjo J. den Broeder, Juliette Legler, Jan Bogerd, Rüdiger W. Schulz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4c9f06c43b914b4998cdd9cfb8ac7e39
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spelling	oai:doaj.org-article:4c9f06c43b914b4998cdd9cfb8ac7e392021-12-02T10:54:22ZInsulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells10.1038/s42003-021-01708-y2399-3642https://doaj.org/article/4c9f06c43b914b4998cdd9cfb8ac7e392021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01708-yhttps://doaj.org/toc/2399-3642Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary. Using insl3 knockout zebrafish, the authors found that Insl3 regulates spermatogonia differentiation and apoptosis via the Pparg and retinoic acid pathways.Diego CrespoLuiz H. C. AssisYu Ting ZhangDiego SafianTomasz FurmanekKai Ove SkaftnesmoBirgitta NorbergWei GeYung-Ching ChoiMarjo J. den BroederJuliette LeglerJan BogerdRüdiger W. SchulzNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Diego Crespo Luiz H. C. Assis Yu Ting Zhang Diego Safian Tomasz Furmanek Kai Ove Skaftnesmo Birgitta Norberg Wei Ge Yung-Ching Choi Marjo J. den Broeder Juliette Legler Jan Bogerd Rüdiger W. Schulz Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
description	Insulin-like 3 (Insl3) belongs to a class of peptide hormones that are expressed in the Leydig cells and, in zebrafish, under the control of folliclestimulating hormone (Fsh) in the pituitary. Using insl3 knockout zebrafish, the authors found that Insl3 regulates spermatogonia differentiation and apoptosis via the Pparg and retinoic acid pathways.
format	article
author	Diego Crespo Luiz H. C. Assis Yu Ting Zhang Diego Safian Tomasz Furmanek Kai Ove Skaftnesmo Birgitta Norberg Wei Ge Yung-Ching Choi Marjo J. den Broeder Juliette Legler Jan Bogerd Rüdiger W. Schulz
author_facet	Diego Crespo Luiz H. C. Assis Yu Ting Zhang Diego Safian Tomasz Furmanek Kai Ove Skaftnesmo Birgitta Norberg Wei Ge Yung-Ching Choi Marjo J. den Broeder Juliette Legler Jan Bogerd Rüdiger W. Schulz
author_sort	Diego Crespo
title	Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
title_short	Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
title_full	Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
title_fullStr	Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
title_full_unstemmed	Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells
title_sort	insulin-like 3 affects zebrafish spermatogenic cells directly and via sertoli cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4c9f06c43b914b4998cdd9cfb8ac7e39
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Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells

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