DNA damage triggers genetic exchange in Helicobacter pylori.

Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein t...

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Autores principales:	Marion S Dorer, Jutta Fero, Nina R Salama
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4ca3f9b0907d439e8732375ff79ace8c
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spelling	oai:doaj.org-article:4ca3f9b0907d439e8732375ff79ace8c2021-11-18T06:01:47ZDNA damage triggers genetic exchange in Helicobacter pylori.1553-73661553-737410.1371/journal.ppat.1001026https://doaj.org/article/4ca3f9b0907d439e8732375ff79ace8c2010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20686662/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA damage response, as both recA and the ability to take up DNA are required for full induction of the response. This feedback loop is active during stomach colonization, indicating a role in the pathogenesis of the bacterium. As patients can be infected with multiple genetically distinct clones of H. pylori, DNA damage induced genetic exchange may facilitate spread of antibiotic resistance and selection of fitter variants through re-assortment of preexisting alleles in this important human pathogen.Marion S DorerJutta FeroNina R SalamaPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 7, p e1001026 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Marion S Dorer Jutta Fero Nina R Salama DNA damage triggers genetic exchange in Helicobacter pylori.
description	Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA damage response, as both recA and the ability to take up DNA are required for full induction of the response. This feedback loop is active during stomach colonization, indicating a role in the pathogenesis of the bacterium. As patients can be infected with multiple genetically distinct clones of H. pylori, DNA damage induced genetic exchange may facilitate spread of antibiotic resistance and selection of fitter variants through re-assortment of preexisting alleles in this important human pathogen.
format	article
author	Marion S Dorer Jutta Fero Nina R Salama
author_facet	Marion S Dorer Jutta Fero Nina R Salama
author_sort	Marion S Dorer
title	DNA damage triggers genetic exchange in Helicobacter pylori.
title_short	DNA damage triggers genetic exchange in Helicobacter pylori.
title_full	DNA damage triggers genetic exchange in Helicobacter pylori.
title_fullStr	DNA damage triggers genetic exchange in Helicobacter pylori.
title_full_unstemmed	DNA damage triggers genetic exchange in Helicobacter pylori.
title_sort	dna damage triggers genetic exchange in helicobacter pylori.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/4ca3f9b0907d439e8732375ff79ace8c
work_keys_str_mv	AT marionsdorer dnadamagetriggersgeneticexchangeinhelicobacterpylori AT juttafero dnadamagetriggersgeneticexchangeinhelicobacterpylori AT ninarsalama dnadamagetriggersgeneticexchangeinhelicobacterpylori
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DNA damage triggers genetic exchange in Helicobacter pylori.

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