Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems

Precisely tuning the genetic response to environmental stimuli is a key step in engineering synthetic biology systems. Here, the authors profile 8269 IPTG-induced promoters to deconstruct the relationship between sequence architecture and gene expression.

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Autores principales:	Timothy C. Yu, Winnie L. Liu, Marcia S. Brinck, Jessica E. Davis, Jeremy Shek, Grace Bower, Tal Einav, Kimberly D. Insigne, Rob Phillips, Sriram Kosuri, Guillaume Urtecho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cab2046d5594f268114bd03aed9a468
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spelling	oai:doaj.org-article:4cab2046d5594f268114bd03aed9a4682021-12-02T14:01:14ZMultiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems10.1038/s41467-020-20094-32041-1723https://doaj.org/article/4cab2046d5594f268114bd03aed9a4682021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20094-3https://doaj.org/toc/2041-1723Precisely tuning the genetic response to environmental stimuli is a key step in engineering synthetic biology systems. Here, the authors profile 8269 IPTG-induced promoters to deconstruct the relationship between sequence architecture and gene expression.Timothy C. YuWinnie L. LiuMarcia S. BrinckJessica E. DavisJeremy ShekGrace BowerTal EinavKimberly D. InsigneRob PhillipsSriram KosuriGuillaume UrtechoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy C. Yu Winnie L. Liu Marcia S. Brinck Jessica E. Davis Jeremy Shek Grace Bower Tal Einav Kimberly D. Insigne Rob Phillips Sriram Kosuri Guillaume Urtecho Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
description	Precisely tuning the genetic response to environmental stimuli is a key step in engineering synthetic biology systems. Here, the authors profile 8269 IPTG-induced promoters to deconstruct the relationship between sequence architecture and gene expression.
format	article
author	Timothy C. Yu Winnie L. Liu Marcia S. Brinck Jessica E. Davis Jeremy Shek Grace Bower Tal Einav Kimberly D. Insigne Rob Phillips Sriram Kosuri Guillaume Urtecho
author_facet	Timothy C. Yu Winnie L. Liu Marcia S. Brinck Jessica E. Davis Jeremy Shek Grace Bower Tal Einav Kimberly D. Insigne Rob Phillips Sriram Kosuri Guillaume Urtecho
author_sort	Timothy C. Yu
title	Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
title_short	Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
title_full	Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
title_fullStr	Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
title_full_unstemmed	Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
title_sort	multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for iptg-inducible systems
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4cab2046d5594f268114bd03aed9a468
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Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems

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