mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances

It was previously suggested that formation of RNA secondary structure tends to bring the 5′ and 3′ ends of RNA into close proximity. Here the authors use experimental and computational approaches to show that mRNAs and lncRNAs have an intrinsic propensity to fold into structures in which the 5′ end...

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Autores principales:	Wan-Jung C. Lai, Mohammad Kayedkhordeh, Erica V. Cornell, Elie Farah, Stanislav Bellaousov, Robert Rietmeijer, Enea Salsi, David H. Mathews, Dmitri N. Ermolenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cabaeef47a048fa92dd9b55643a6ce8
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spelling	oai:doaj.org-article:4cabaeef47a048fa92dd9b55643a6ce82021-12-02T17:33:05ZmRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances10.1038/s41467-018-06792-z2041-1723https://doaj.org/article/4cabaeef47a048fa92dd9b55643a6ce82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06792-zhttps://doaj.org/toc/2041-1723It was previously suggested that formation of RNA secondary structure tends to bring the 5′ and 3′ ends of RNA into close proximity. Here the authors use experimental and computational approaches to show that mRNAs and lncRNAs have an intrinsic propensity to fold into structures in which the 5′ end and 3′ end are ≤7 nm apart irrespective of length.Wan-Jung C. LaiMohammad KayedkhordehErica V. CornellElie FarahStanislav BellaousovRobert RietmeijerEnea SalsiDavid H. MathewsDmitri N. ErmolenkoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wan-Jung C. Lai Mohammad Kayedkhordeh Erica V. Cornell Elie Farah Stanislav Bellaousov Robert Rietmeijer Enea Salsi David H. Mathews Dmitri N. Ermolenko mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
description	It was previously suggested that formation of RNA secondary structure tends to bring the 5′ and 3′ ends of RNA into close proximity. Here the authors use experimental and computational approaches to show that mRNAs and lncRNAs have an intrinsic propensity to fold into structures in which the 5′ end and 3′ end are ≤7 nm apart irrespective of length.
format	article
author	Wan-Jung C. Lai Mohammad Kayedkhordeh Erica V. Cornell Elie Farah Stanislav Bellaousov Robert Rietmeijer Enea Salsi David H. Mathews Dmitri N. Ermolenko
author_facet	Wan-Jung C. Lai Mohammad Kayedkhordeh Erica V. Cornell Elie Farah Stanislav Bellaousov Robert Rietmeijer Enea Salsi David H. Mathews Dmitri N. Ermolenko
author_sort	Wan-Jung C. Lai
title	mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
title_short	mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
title_full	mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
title_fullStr	mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
title_full_unstemmed	mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances
title_sort	mrnas and lncrnas intrinsically form secondary structures with short end-to-end distances
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4cabaeef47a048fa92dd9b55643a6ce8
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mRNAs and lncRNAs intrinsically form secondary structures with short end-to-end distances

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