Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis

Abstract Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indi...

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Autores principales:	Nobuo Kuramoto, Koichiro Ohmura, Katsunori Ikari, Koichiro Yano, Moritoshi Furu, Noriyuki Yamakawa, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Kosaku Murakami, Ran Nakashima, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Atsuo Taniguchi, Shigeki Momohara, Hisashi Yamanaka, Fumihiko Matsuda, Tsuneyo Mimori, Chikashi Terao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4cade095549249a181002716d88d253e
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spelling	oai:doaj.org-article:4cade095549249a181002716d88d253e2021-12-02T16:06:34ZAnti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis10.1038/s41598-017-07137-42045-2322https://doaj.org/article/4cade095549249a181002716d88d253e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07137-4https://doaj.org/toc/2045-2322Abstract Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3,353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features.Nobuo KuramotoKoichiro OhmuraKatsunori IkariKoichiro YanoMoritoshi FuruNoriyuki YamakawaMotomu HashimotoHiromu ItoTakao FujiiKosaku MurakamiRan NakashimaYoshitaka ImuraNaoichiro YukawaHajime YoshifujiAtsuo TaniguchiShigeki MomoharaHisashi YamanakaFumihiko MatsudaTsuneyo MimoriChikashi TeraoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nobuo Kuramoto Koichiro Ohmura Katsunori Ikari Koichiro Yano Moritoshi Furu Noriyuki Yamakawa Motomu Hashimoto Hiromu Ito Takao Fujii Kosaku Murakami Ran Nakashima Yoshitaka Imura Naoichiro Yukawa Hajime Yoshifuji Atsuo Taniguchi Shigeki Momohara Hisashi Yamanaka Fumihiko Matsuda Tsuneyo Mimori Chikashi Terao Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
description	Abstract Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3,353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features.
format	article
author	Nobuo Kuramoto Koichiro Ohmura Katsunori Ikari Koichiro Yano Moritoshi Furu Noriyuki Yamakawa Motomu Hashimoto Hiromu Ito Takao Fujii Kosaku Murakami Ran Nakashima Yoshitaka Imura Naoichiro Yukawa Hajime Yoshifuji Atsuo Taniguchi Shigeki Momohara Hisashi Yamanaka Fumihiko Matsuda Tsuneyo Mimori Chikashi Terao
author_facet	Nobuo Kuramoto Koichiro Ohmura Katsunori Ikari Koichiro Yano Moritoshi Furu Noriyuki Yamakawa Motomu Hashimoto Hiromu Ito Takao Fujii Kosaku Murakami Ran Nakashima Yoshitaka Imura Naoichiro Yukawa Hajime Yoshifuji Atsuo Taniguchi Shigeki Momohara Hisashi Yamanaka Fumihiko Matsuda Tsuneyo Mimori Chikashi Terao
author_sort	Nobuo Kuramoto
title	Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
title_short	Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
title_full	Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
title_fullStr	Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
title_full_unstemmed	Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
title_sort	anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4cade095549249a181002716d88d253e
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Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis

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