Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

Volume-regulated anion channels (VRACs) are heteromers of LRRC8 proteins, all containing the obligatory subunit LRRC8A. Here, the authors develop and characterize nanobodies that bind LRRC8A and allosterically modulate the function of homomeric LRRC8A and endogenous heteromeric channels, hinting at...

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Autores principales:	Dawid Deneka, Sonja Rutz, Cedric A. J. Hutter, Markus A. Seeger, Marta Sawicka, Raimund Dutzler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4caeef50636c4f189a4fe60799bf32be
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spelling	oai:doaj.org-article:4caeef50636c4f189a4fe60799bf32be2021-12-02T17:24:13ZAllosteric modulation of LRRC8 channels by targeting their cytoplasmic domains10.1038/s41467-021-25742-w2041-1723https://doaj.org/article/4caeef50636c4f189a4fe60799bf32be2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25742-whttps://doaj.org/toc/2041-1723Volume-regulated anion channels (VRACs) are heteromers of LRRC8 proteins, all containing the obligatory subunit LRRC8A. Here, the authors develop and characterize nanobodies that bind LRRC8A and allosterically modulate the function of homomeric LRRC8A and endogenous heteromeric channels, hinting at functional mechanisms present in VRACs.Dawid DenekaSonja RutzCedric A. J. HutterMarkus A. SeegerMarta SawickaRaimund DutzlerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dawid Deneka Sonja Rutz Cedric A. J. Hutter Markus A. Seeger Marta Sawicka Raimund Dutzler Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
description	Volume-regulated anion channels (VRACs) are heteromers of LRRC8 proteins, all containing the obligatory subunit LRRC8A. Here, the authors develop and characterize nanobodies that bind LRRC8A and allosterically modulate the function of homomeric LRRC8A and endogenous heteromeric channels, hinting at functional mechanisms present in VRACs.
format	article
author	Dawid Deneka Sonja Rutz Cedric A. J. Hutter Markus A. Seeger Marta Sawicka Raimund Dutzler
author_facet	Dawid Deneka Sonja Rutz Cedric A. J. Hutter Markus A. Seeger Marta Sawicka Raimund Dutzler
author_sort	Dawid Deneka
title	Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
title_short	Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
title_full	Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
title_fullStr	Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
title_full_unstemmed	Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains
title_sort	allosteric modulation of lrrc8 channels by targeting their cytoplasmic domains
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4caeef50636c4f189a4fe60799bf32be
work_keys_str_mv	AT dawiddeneka allostericmodulationoflrrc8channelsbytargetingtheircytoplasmicdomains AT sonjarutz allostericmodulationoflrrc8channelsbytargetingtheircytoplasmicdomains AT cedricajhutter allostericmodulationoflrrc8channelsbytargetingtheircytoplasmicdomains AT markusaseeger allostericmodulationoflrrc8channelsbytargetingtheircytoplasmicdomains AT martasawicka allostericmodulationoflrrc8channelsbytargetingtheircytoplasmicdomains AT raimunddutzler allostericmodulationoflrrc8channelsbytargetingtheircytoplasmicdomains
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Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

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