Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

It’s well known that hippocampal synaptic plasticity and memory are impaired in experimental models of metabolic diseases, however, it is unclear if maternal diet or metabolic alterations around the gestational age may multigenerationally affect learning and memory. In this study, authors demonstrat...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Salvatore Fusco, Matteo Spinelli, Sara Cocco, Cristian Ripoli, Alessia Mastrodonato, Francesca Natale, Marco Rinaudo, Giulia Livrizzi, Claudio Grassi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/4cb241068bf443d786239ed236081505
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:It’s well known that hippocampal synaptic plasticity and memory are impaired in experimental models of metabolic diseases, however, it is unclear if maternal diet or metabolic alterations around the gestational age may multigenerationally affect learning and memory. In this study, authors demonstrate that maternal high fat diet-dependent insulin resistance affects synaptic plasticity and memory of descendants until the third generation via reduced exon specific brain-derived neurotrophic factor expression in the hippocampus of descendants