Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

It’s well known that hippocampal synaptic plasticity and memory are impaired in experimental models of metabolic diseases, however, it is unclear if maternal diet or metabolic alterations around the gestational age may multigenerationally affect learning and memory. In this study, authors demonstrat...

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Autores principales:	Salvatore Fusco, Matteo Spinelli, Sara Cocco, Cristian Ripoli, Alessia Mastrodonato, Francesca Natale, Marco Rinaudo, Giulia Livrizzi, Claudio Grassi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cb241068bf443d786239ed236081505
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spelling	oai:doaj.org-article:4cb241068bf443d786239ed2360815052021-12-02T16:58:16ZMaternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms10.1038/s41467-019-12793-32041-1723https://doaj.org/article/4cb241068bf443d786239ed2360815052019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12793-3https://doaj.org/toc/2041-1723It’s well known that hippocampal synaptic plasticity and memory are impaired in experimental models of metabolic diseases, however, it is unclear if maternal diet or metabolic alterations around the gestational age may multigenerationally affect learning and memory. In this study, authors demonstrate that maternal high fat diet-dependent insulin resistance affects synaptic plasticity and memory of descendants until the third generation via reduced exon specific brain-derived neurotrophic factor expression in the hippocampus of descendantsSalvatore FuscoMatteo SpinelliSara CoccoCristian RipoliAlessia MastrodonatoFrancesca NataleMarco RinaudoGiulia LivrizziClaudio GrassiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Salvatore Fusco Matteo Spinelli Sara Cocco Cristian Ripoli Alessia Mastrodonato Francesca Natale Marco Rinaudo Giulia Livrizzi Claudio Grassi Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
description	It’s well known that hippocampal synaptic plasticity and memory are impaired in experimental models of metabolic diseases, however, it is unclear if maternal diet or metabolic alterations around the gestational age may multigenerationally affect learning and memory. In this study, authors demonstrate that maternal high fat diet-dependent insulin resistance affects synaptic plasticity and memory of descendants until the third generation via reduced exon specific brain-derived neurotrophic factor expression in the hippocampus of descendants
format	article
author	Salvatore Fusco Matteo Spinelli Sara Cocco Cristian Ripoli Alessia Mastrodonato Francesca Natale Marco Rinaudo Giulia Livrizzi Claudio Grassi
author_facet	Salvatore Fusco Matteo Spinelli Sara Cocco Cristian Ripoli Alessia Mastrodonato Francesca Natale Marco Rinaudo Giulia Livrizzi Claudio Grassi
author_sort	Salvatore Fusco
title	Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
title_short	Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
title_full	Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
title_fullStr	Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
title_full_unstemmed	Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
title_sort	maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4cb241068bf443d786239ed236081505
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Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

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