IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice

The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer’s patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of γδ T cells in the GC reactions in PPs. Most...

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Autores principales:	Leon Ullrich, Yvonne Lueder, Anna-Lena Juergens, Anneke Wilharm, Joana Barros-Martins, Anja Bubke, Abdi Demera, Koichi Ikuta, Gwendolyn Elena Patzer, Anika Janssen, Inga Sandrock, Immo Prinz, Francesca Rampoldi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	germinal center Peyer’s patches γδ T cells Vγ1+ T cells IL-4 IgA Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4cb32a24dbce4fc98e5a56dd8eee30a9
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spelling	oai:doaj.org-article:4cb32a24dbce4fc98e5a56dd8eee30a92021-11-04T11:42:33ZIL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice1664-322410.3389/fimmu.2021.729607https://doaj.org/article/4cb32a24dbce4fc98e5a56dd8eee30a92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.729607/fullhttps://doaj.org/toc/1664-3224The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer’s patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of γδ T cells in the GC reactions in PPs. Most γδ T cells in PPs localized in the GCs and expressed a TCR composed of Vγ1 and Vδ6 chains. By using mice with partial and total γδ T cell deficiencies, we found that Vγ1+/Vδ6+ T cells can produce high amounts of IL-4, which drives the proliferation of GC B cells as well as the switch of GC B cells towards IgA. Therefore, we conclude that γδ T cells play a role in sustaining gut homeostasis and symbiosis via supporting the GC reactions in PPs.Leon UllrichYvonne LuederAnna-Lena JuergensAnneke WilharmJoana Barros-MartinsAnja BubkeAbdi DemeraKoichi IkutaGwendolyn Elena PatzerAnika JanssenInga SandrockImmo PrinzImmo PrinzFrancesca RampoldiFrontiers Media S.A.articlegerminal centerPeyer’s patchesγδ T cellsVγ1+ T cellsIL-4IgAImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	germinal center Peyer’s patches γδ T cells Vγ1+ T cells IL-4 IgA Immunologic diseases. Allergy RC581-607
spellingShingle	germinal center Peyer’s patches γδ T cells Vγ1+ T cells IL-4 IgA Immunologic diseases. Allergy RC581-607 Leon Ullrich Yvonne Lueder Anna-Lena Juergens Anneke Wilharm Joana Barros-Martins Anja Bubke Abdi Demera Koichi Ikuta Gwendolyn Elena Patzer Anika Janssen Inga Sandrock Immo Prinz Immo Prinz Francesca Rampoldi IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice
description	The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer’s patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of γδ T cells in the GC reactions in PPs. Most γδ T cells in PPs localized in the GCs and expressed a TCR composed of Vγ1 and Vδ6 chains. By using mice with partial and total γδ T cell deficiencies, we found that Vγ1+/Vδ6+ T cells can produce high amounts of IL-4, which drives the proliferation of GC B cells as well as the switch of GC B cells towards IgA. Therefore, we conclude that γδ T cells play a role in sustaining gut homeostasis and symbiosis via supporting the GC reactions in PPs.
format	article
author	Leon Ullrich Yvonne Lueder Anna-Lena Juergens Anneke Wilharm Joana Barros-Martins Anja Bubke Abdi Demera Koichi Ikuta Gwendolyn Elena Patzer Anika Janssen Inga Sandrock Immo Prinz Immo Prinz Francesca Rampoldi
author_facet	Leon Ullrich Yvonne Lueder Anna-Lena Juergens Anneke Wilharm Joana Barros-Martins Anja Bubke Abdi Demera Koichi Ikuta Gwendolyn Elena Patzer Anika Janssen Inga Sandrock Immo Prinz Immo Prinz Francesca Rampoldi
author_sort	Leon Ullrich
title	IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice
title_short	IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice
title_full	IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice
title_fullStr	IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice
title_full_unstemmed	IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice
title_sort	il-4-producing vγ1+/vδ6+ γδ t cells sustain germinal center reactions in peyer’s patches of mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4cb32a24dbce4fc98e5a56dd8eee30a9
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IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer’s Patches of Mice

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