Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-W...
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Nature Portfolio
2019
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oai:doaj.org-article:4cb4bba947a8460babf1f27b9cb22a732021-12-02T16:58:26ZIndustrial scale high-throughput screening delivers multiple fast acting macrofilaricides10.1038/s41467-018-07826-22041-1723https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a732019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07826-2https://doaj.org/toc/2041-1723Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-Wolbachia drugs.Rachel H. ClareCatherine BardellePaul HarperW. David HongUlf BörjessonKelly L. JohnstonMatthew CollierLaura MyhillAndrew CassidyDarren PlantHelen PlantRoger ClarkDarren A. N. CookAndrew StevenJohn ArcherPaul McGillanSitthivut CharoensutthivarakulJaclyn BibbyRaman SharmaGemma L. NixonBarton E. SlatkoLindsey CantinBo WuJoseph TurnerLouise FordKirsty RichMark WigglesworthNeil G. BerryPaul M. O’NeillMark J. TaylorStephen A. WardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Rachel H. Clare Catherine Bardelle Paul Harper W. David Hong Ulf Börjesson Kelly L. Johnston Matthew Collier Laura Myhill Andrew Cassidy Darren Plant Helen Plant Roger Clark Darren A. N. Cook Andrew Steven John Archer Paul McGillan Sitthivut Charoensutthivarakul Jaclyn Bibby Raman Sharma Gemma L. Nixon Barton E. Slatko Lindsey Cantin Bo Wu Joseph Turner Louise Ford Kirsty Rich Mark Wigglesworth Neil G. Berry Paul M. O’Neill Mark J. Taylor Stephen A. Ward Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| description |
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-Wolbachia drugs. |
| format |
article |
| author |
Rachel H. Clare Catherine Bardelle Paul Harper W. David Hong Ulf Börjesson Kelly L. Johnston Matthew Collier Laura Myhill Andrew Cassidy Darren Plant Helen Plant Roger Clark Darren A. N. Cook Andrew Steven John Archer Paul McGillan Sitthivut Charoensutthivarakul Jaclyn Bibby Raman Sharma Gemma L. Nixon Barton E. Slatko Lindsey Cantin Bo Wu Joseph Turner Louise Ford Kirsty Rich Mark Wigglesworth Neil G. Berry Paul M. O’Neill Mark J. Taylor Stephen A. Ward |
| author_facet |
Rachel H. Clare Catherine Bardelle Paul Harper W. David Hong Ulf Börjesson Kelly L. Johnston Matthew Collier Laura Myhill Andrew Cassidy Darren Plant Helen Plant Roger Clark Darren A. N. Cook Andrew Steven John Archer Paul McGillan Sitthivut Charoensutthivarakul Jaclyn Bibby Raman Sharma Gemma L. Nixon Barton E. Slatko Lindsey Cantin Bo Wu Joseph Turner Louise Ford Kirsty Rich Mark Wigglesworth Neil G. Berry Paul M. O’Neill Mark J. Taylor Stephen A. Ward |
| author_sort |
Rachel H. Clare |
| title |
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| title_short |
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| title_full |
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| title_fullStr |
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| title_full_unstemmed |
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| title_sort |
industrial scale high-throughput screening delivers multiple fast acting macrofilaricides |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73 |
| work_keys_str_mv |
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