First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias

Abstract We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to ide...

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Autores principales:	Li-Ting Ho, Jenny Ling-Yu Chen, Hsing-Min Chan, Yu-Cheng Huang, Mao-Yuan Su, Sung-Hsin Kuo, Yeun-Chung Chang, Jiunn-Lee Lin, Wen-Jone Chen, Wen-Jeng Lee, Lian-Yu Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4cb7dd5e1eb146689d601515e02fad1c
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spelling	oai:doaj.org-article:4cb7dd5e1eb146689d601515e02fad1c2021-12-02T17:15:36ZFirst Asian population study of stereotactic body radiation therapy for ventricular arrhythmias10.1038/s41598-021-89857-22045-2322https://doaj.org/article/4cb7dd5e1eb146689d601515e02fad1c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89857-2https://doaj.org/toc/2045-2322Abstract We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to identify scar substrates. The main target volume was treated with a single radiation dose of 25 Gy and the margin volume received 20 Gy using simultaneous integrated boost delivered by the Varian TrueBeam system. Efficacy was assessed according to VA events recorded by an implantable cardioverter-defibrillator (ICD) or a 24-h Holter recorder. Pre- and post-radiation therapy imaging studies were performed. From February 2019 to December 2019, seven patients (six men, one woman; mean age, 55 years) were enrolled and treated. One patient died of hepatic failure. In the remaining six patients, at a median follow-up of 14.5 months, the VA burden and ICD shocks significantly decreased (only one patient with one ICD shock after treatment). Increased intensity on DE-MRI might be associated with a lower risk for VA recurrence, whereas dual-energy CT had lower detection sensitivity. No acute or minimal late adverse events occurred. In patients with refractory VA, SBRT is associated with a marked reduction in VA burden and ICD shocks, and DE-MRI might be useful for monitoring treatment effects.Li-Ting HoJenny Ling-Yu ChenHsing-Min ChanYu-Cheng HuangMao-Yuan SuSung-Hsin KuoYeun-Chung ChangJiunn-Lee LinWen-Jone ChenWen-Jeng LeeLian-Yu LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li-Ting Ho Jenny Ling-Yu Chen Hsing-Min Chan Yu-Cheng Huang Mao-Yuan Su Sung-Hsin Kuo Yeun-Chung Chang Jiunn-Lee Lin Wen-Jone Chen Wen-Jeng Lee Lian-Yu Lin First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias
description	Abstract We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to identify scar substrates. The main target volume was treated with a single radiation dose of 25 Gy and the margin volume received 20 Gy using simultaneous integrated boost delivered by the Varian TrueBeam system. Efficacy was assessed according to VA events recorded by an implantable cardioverter-defibrillator (ICD) or a 24-h Holter recorder. Pre- and post-radiation therapy imaging studies were performed. From February 2019 to December 2019, seven patients (six men, one woman; mean age, 55 years) were enrolled and treated. One patient died of hepatic failure. In the remaining six patients, at a median follow-up of 14.5 months, the VA burden and ICD shocks significantly decreased (only one patient with one ICD shock after treatment). Increased intensity on DE-MRI might be associated with a lower risk for VA recurrence, whereas dual-energy CT had lower detection sensitivity. No acute or minimal late adverse events occurred. In patients with refractory VA, SBRT is associated with a marked reduction in VA burden and ICD shocks, and DE-MRI might be useful for monitoring treatment effects.
format	article
author	Li-Ting Ho Jenny Ling-Yu Chen Hsing-Min Chan Yu-Cheng Huang Mao-Yuan Su Sung-Hsin Kuo Yeun-Chung Chang Jiunn-Lee Lin Wen-Jone Chen Wen-Jeng Lee Lian-Yu Lin
author_facet	Li-Ting Ho Jenny Ling-Yu Chen Hsing-Min Chan Yu-Cheng Huang Mao-Yuan Su Sung-Hsin Kuo Yeun-Chung Chang Jiunn-Lee Lin Wen-Jone Chen Wen-Jeng Lee Lian-Yu Lin
author_sort	Li-Ting Ho
title	First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias
title_short	First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias
title_full	First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias
title_fullStr	First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias
title_full_unstemmed	First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias
title_sort	first asian population study of stereotactic body radiation therapy for ventricular arrhythmias
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4cb7dd5e1eb146689d601515e02fad1c
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First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias

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