Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy

Introduction: Nephrotic syndrome is one of the most common glomerular diseases in children who are also at risk of metabolic bone diseases. In this study the effect of supplementary use of vitamin D3 was assessed on serum levels of vitamin D3 in patients with nephrotic syndrome receiving steroid the...

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Autores principales:	Hashem Mahmoodzadeh, Mohammad Valizadeh, Ahmadali Nikibakhsh, Ezatollah Abbasi
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2020
Materias:	nephrotic syndrome serum vitamin d3 level glucocorticoids vitamin d supplementation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4cb8993a71a34082be29707974fac85d
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spelling	oai:doaj.org-article:4cb8993a71a34082be29707974fac85d2021-11-17T09:54:52ZEffects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy2476-664X10.34172/ijbsm.2020.25https://doaj.org/article/4cb8993a71a34082be29707974fac85d2020-12-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-21456https://doaj.org/toc/2476-664XIntroduction: Nephrotic syndrome is one of the most common glomerular diseases in children who are also at risk of metabolic bone diseases. In this study the effect of supplementary use of vitamin D3 was assessed on serum levels of vitamin D3 in patients with nephrotic syndrome receiving steroid therapy. Methods: Thirty children with nephrotic syndrome were included in this study. After obtaining blood samples to measure 25(OH) D levels, all patients were supplemented with daily doses of Vitamin D for one month. Serum 25(OH) D level was checked again, and these patients were supplemented for another month if they had been recognized with deficiency at the last check. Results: Out of 30 children, 60% were male and 40% were female with a mean age of 6.91 ± 3.34 years. Before intervention, 70% of patients had severe vitamin D deficiency, and 26.7% had mild to moderate deficiency, and none of the patients had normal serum levels of 25-(OH)-D. After one month, only one patient gained normal levels which was not statistically significant (P=0.500). After two months of intervention, 12 patients escaped deficiency but still exhibited insufficient levels followed by 8 people with deficiency, and 10 patients reached normal values which was statistically significant (P=0.002). The mean level of 25(OH) D was 8.277±0.84 ng/ mL rising to 14.364±1.14 ng/mL after two months (P=0.001). Conclusion: This study showed a high incidence of vitamin D deficiency in the children with nephrotic syndrome warranting routine surveillance of vitamin D serum levels in these patients. Daily doses of vitamin D in the first month of onset of the disease was insufficient. We suggest that children may benefit from routine measurement of their serum vitamin D from diagnosis and later in follow-up visits so an individual strategy for vitamin D supplementation could be given.Hashem MahmoodzadehMohammad ValizadehAhmadali NikibakhshEzatollah AbbasiZabol University of Medical sciencesarticlenephrotic syndrome serum vitamin d3 level glucocorticoids vitamin d supplementation Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 5, Iss 4, Pp 142-146 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	nephrotic syndrome serum vitamin d3 level glucocorticoids vitamin d supplementation Medicine (General) R5-920
spellingShingle	nephrotic syndrome serum vitamin d3 level glucocorticoids vitamin d supplementation Medicine (General) R5-920 Hashem Mahmoodzadeh Mohammad Valizadeh Ahmadali Nikibakhsh Ezatollah Abbasi Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy
description	Introduction: Nephrotic syndrome is one of the most common glomerular diseases in children who are also at risk of metabolic bone diseases. In this study the effect of supplementary use of vitamin D3 was assessed on serum levels of vitamin D3 in patients with nephrotic syndrome receiving steroid therapy. Methods: Thirty children with nephrotic syndrome were included in this study. After obtaining blood samples to measure 25(OH) D levels, all patients were supplemented with daily doses of Vitamin D for one month. Serum 25(OH) D level was checked again, and these patients were supplemented for another month if they had been recognized with deficiency at the last check. Results: Out of 30 children, 60% were male and 40% were female with a mean age of 6.91 ± 3.34 years. Before intervention, 70% of patients had severe vitamin D deficiency, and 26.7% had mild to moderate deficiency, and none of the patients had normal serum levels of 25-(OH)-D. After one month, only one patient gained normal levels which was not statistically significant (P=0.500). After two months of intervention, 12 patients escaped deficiency but still exhibited insufficient levels followed by 8 people with deficiency, and 10 patients reached normal values which was statistically significant (P=0.002). The mean level of 25(OH) D was 8.277±0.84 ng/ mL rising to 14.364±1.14 ng/mL after two months (P=0.001). Conclusion: This study showed a high incidence of vitamin D deficiency in the children with nephrotic syndrome warranting routine surveillance of vitamin D serum levels in these patients. Daily doses of vitamin D in the first month of onset of the disease was insufficient. We suggest that children may benefit from routine measurement of their serum vitamin D from diagnosis and later in follow-up visits so an individual strategy for vitamin D supplementation could be given.
format	article
author	Hashem Mahmoodzadeh Mohammad Valizadeh Ahmadali Nikibakhsh Ezatollah Abbasi
author_facet	Hashem Mahmoodzadeh Mohammad Valizadeh Ahmadali Nikibakhsh Ezatollah Abbasi
author_sort	Hashem Mahmoodzadeh
title	Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy
title_short	Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy
title_full	Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy
title_fullStr	Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy
title_full_unstemmed	Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy
title_sort	effects of supplementary vitamin d on vitamin d3 serum level in nephrotic syndrome patients receiving steroid therapy
publisher	Zabol University of Medical sciences
publishDate	2020
url	https://doaj.org/article/4cb8993a71a34082be29707974fac85d
work_keys_str_mv	AT hashemmahmoodzadeh effectsofsupplementaryvitamindonvitamind3serumlevelinnephroticsyndromepatientsreceivingsteroidtherapy AT mohammadvalizadeh effectsofsupplementaryvitamindonvitamind3serumlevelinnephroticsyndromepatientsreceivingsteroidtherapy AT ahmadalinikibakhsh effectsofsupplementaryvitamindonvitamind3serumlevelinnephroticsyndromepatientsreceivingsteroidtherapy AT ezatollahabbasi effectsofsupplementaryvitamindonvitamind3serumlevelinnephroticsyndromepatientsreceivingsteroidtherapy
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Effects of Supplementary Vitamin D on Vitamin D3 Serum Level in Nephrotic Syndrome Patients Receiving Steroid Therapy

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