Coordinated integrin activation by actin-dependent force during T-cell migration

The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state.

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Detalles Bibliográficos
Autores principales:	Pontus Nordenfelt, Hunter L. Elliott, Timothy A. Springer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cb97213161945028795dbc0972b0aec
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spelling	oai:doaj.org-article:4cb97213161945028795dbc0972b0aec2021-12-02T17:33:07ZCoordinated integrin activation by actin-dependent force during T-cell migration10.1038/ncomms131192041-1723https://doaj.org/article/4cb97213161945028795dbc0972b0aec2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13119https://doaj.org/toc/2041-1723The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state.Pontus NordenfeltHunter L. ElliottTimothy A. SpringerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pontus Nordenfelt Hunter L. Elliott Timothy A. Springer Coordinated integrin activation by actin-dependent force during T-cell migration
description	The role of force in activating integrin cell adhesion receptors is not known. Here the authors develop fluorescent tension sensors for αL and β2 integrins and show that in migrating T cells force is transduced across the β2 integrin, and that this correlates with an active conformational state.
format	article
author	Pontus Nordenfelt Hunter L. Elliott Timothy A. Springer
author_facet	Pontus Nordenfelt Hunter L. Elliott Timothy A. Springer
author_sort	Pontus Nordenfelt
title	Coordinated integrin activation by actin-dependent force during T-cell migration
title_short	Coordinated integrin activation by actin-dependent force during T-cell migration
title_full	Coordinated integrin activation by actin-dependent force during T-cell migration
title_fullStr	Coordinated integrin activation by actin-dependent force during T-cell migration
title_full_unstemmed	Coordinated integrin activation by actin-dependent force during T-cell migration
title_sort	coordinated integrin activation by actin-dependent force during t-cell migration
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4cb97213161945028795dbc0972b0aec
work_keys_str_mv	AT pontusnordenfelt coordinatedintegrinactivationbyactindependentforceduringtcellmigration AT hunterlelliott coordinatedintegrinactivationbyactindependentforceduringtcellmigration AT timothyaspringer coordinatedintegrinactivationbyactindependentforceduringtcellmigration
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Coordinated integrin activation by actin-dependent force during T-cell migration

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