Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

Type 1 diabetes (T1D) is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothelial cells (EC) lining capillary walls into the is...

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Autores principales:	Lucas H. Armitage, Scott E. Stimpson, Katherine E. Santostefano, Lina Sui, Similoluwa Ogundare, Brittney N. Newby, Roberto Castro-Gutierrez, Mollie K. Huber, Jared P. Taylor, Prerana Sharma, Ilian A. Radichev, Daniel J. Perry, Natalie C. Fredette, Alexei Y. Savinov, Mark A. Wallet, Naohiro Terada, Todd M. Brusko, Holger A. Russ, Jing Chen, Dieter Egli, Clayton E. Mathews
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	type 1 diabetes mellitus isogenic human beta cells immunity autoimmunity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/4cc69f69404e4a1aa049c8589a0add98
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Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

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